73428-02-1Relevant articles and documents
BIARYLTRIAZOLE INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR
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Page/Page column 187, (2016/09/22)
The present disclosure describes biaryl triazole compounds, as well as their compositions and methods of use. The compounds inhibit the activity of macrophage migration inhibitory factor and are useful for the treatment of diseases, e.g., inflammatory dis
Heterobicyclic sphingosine 1-phosphate analogs
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Page/Page column, (2014/04/18)
Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
Design and synthesis of 6,6-fused heterocyclic amides as raf kinase inhibitors
Ramurthy, Savithri,Costales, Abran,Jansen, Johanna M.,Levine, Barry,Renhowe, Paul A.,Shafer, Cynthia M.,Subramanian, Sharadha
supporting information; experimental part, p. 1678 - 1681 (2012/04/04)
Compounds belonging to several scaffolds-quinazolines, quinolines and quinoxalines-were designed and synthesized as Raf kinase inhibitors. Scaffolds were assessed for in vitro BrafV600E inhibition, and overall kinase selectivity. Pharmacokinetic parameters for one of the scaffolds were also determined.
HETEROBICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS
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Page/Page column 46, (2010/05/14)
Compounds that have agonist activity at one or more of the SlP receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at SlP receptors.
2,6-Disubstituted quinazolines, quinoxalines, quinolines and isoquinolines and methods of their use as inhibitors of RAF kinase
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Page/Page column 13-14; 17, (2010/02/11)
New substituted quinazoline, quinoxaline, quinoline and isoquinoline compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.
Plant antitumor agents: Synthesis and biological activity of camptothecin analogues
Wani,Ronman,Lindley,Wall
, p. 554 - 560 (2007/10/02)
Four analogues, 10-methoxy (20), 12-aza (29), benz[j] (36), and 18-methoxy (38), of camptothecin were obtained by total synthesis. The two water-soluble analogues, 10-[(carboxymethyl)oxy] (24) and 10-[2'-(diethylamino)-ethoxy]-20(S)-camptothecin (26), wit