7343-12-6

Usage

General Description

(2E)-N-(2,4-dimethylphenyl)-2-(hydroxyimino)acetamide is a chemical compound with the molecular formula C12H14N2O2. It is an organic compound with a hydroxyimino functional group, which makes it a key intermediate in the synthesis of various pharmaceuticals. (2E)-N-(2,4-DIMETHYLPHENYL)-2-(HYDROXYIMINO)ACETAMIDE has potential applications in medicinal chemistry, drug design, and the development of new therapeutic agents. It is believed to have properties that make it suitable for use in the treatment of certain medical conditions. Due to its structural composition, it has been a subject of interest in the field of chemistry and pharmacology. Its properties and potential uses are still being researched and studied.

InChI:InChI=1/C10H12N2O2/c1-7-3-4-9(8(2)5-7)12-10(13)6-11-14/h3-6,14H,1-2H3,(H,12,13)/b11-6+

Upstream product

• 302-17-0 chloral hydrate 
• 95-68-1 2,4-Xylidine 
• 75-87-6 chloral 

Downstream Products

• 17825-38-6 (+/-)-2,4,5,7-Tetramethyl-9,10-phenanthrenequinone 
• 14438-32-5 3,5-dimethylanthranilic acid 

Relevant academic research and scientific papers

Study on synthesis of some substituted N-propargyl isatins by propargylation reaction of corresponding isatins using potassium carbonate as base under ultrasound- and microwave-assisted conditions

Substituted N-propargyl isatins were synthesized by SN2 reaction of corresponding substituted isatins with propargyl bromide in the presence of anhydrous K2CO3 as base. We reported about study on systematically synthesis of these compounds using heating procedures under different reaction conditions, including microwave-assisted heating conditions at power of 100?W (Procedure A), conventional heating conditions in water bath at 50?°C in acetonitrile (Procedure B), and conventional heating conditions in water bath at 50?°C in DMF (procedure C). The best procedure A was deduced based on the investigations on the reaction conditions. Almost all substituted N-propargyl isatins were new, except compounds with R of H, 5-Me, 5-Cl and 5-Br substituents. The structures of the obtained compounds were confirmed by the modern spectroscopic methods.

Design, synthesis and antiproliferative activity of novel benzothiazole derivatives conjugated with semicarbazone scaffold

Two series of novel benzothiazole derivatives conjugated with semicarbazone scaffold were designed and synthesized through a structure-based molecular hybridization strategy. All the target compounds were evaluated for their cytotoxicity in vitro against three cancer cell lines (HT-29, MKN-45 and H460) by standard MTT assay. The pharmacological results indicated that seven compounds (17h-n) exhibited comparable or even better antiproliferative activity in comparison with reference drugs Sorafenib and PAC-1. Particularly, compound 17i displayed remarkable cytotoxicity against tested three cancer cell lines with IC50 values of 0.84, 0.06 and 0.52 μM, which were 4.3-, 36.6-, 4.2-folds more potent than Sorafenib and 1.2-, 13.7-, 6.9-times more active than PAC-1, respectively.

Thermal decomposition modes for four-coordinate ruthenium phosphonium alkylidene olefin metathesis catalysts

The four-coordinate ruthenium phosphonium alkylidenes 1-Cy and 1-iPr, differing in the substituent on the phosphorus center, were observed to decompose thermally in the presence of 1,1-dichloroethylene to produce [H 3CPR3][Cl]. The m

Microwave-induced synthesis of spirothiazinane>-2,4'-diones

An efficient method for the synthesis of fluorine containing spirothiazinane>-2,4'-diones, by an elegant one-step procedure under microwave irradiation, is described. Results were compared with those obtained following the classical me