73445-45-1Relevant academic research and scientific papers
Triorganoindium reagents in selective palladium-catalyzed cross-coupling with iodoimidazoles: Synthesis of neurodazine
Prez-Caaveiro, Cristina,Prez Sestelo, Jos,Martnez, M. Montserrat,Sarandeses, Luis A.
, p. 9586 - 9593 (2015/02/19)
Triorganoindium reagents (R3In, R = aryl, heteroaryl, alkynyl) react selectively under palladium catalysis with N-benzyl-2,4,5-triiodoimidazole to afford the C-2 monocoupling products. The reaction proceeds efficiently for a variety of aryl- and heteroarylindium reagents with the transfer of all three organic groups attached to the metal. The coupling products can be used in a subsequent two-fold cross-coupling to give trisubstituted imidazoles in good yields. This approach was employed to synthesize neurodazine and analogues in good yields. (Chemical Equation Presented).
Silica-bonded S-sulfonic acid: A recyclable catalyst for the synthesis of trisubstituted imidazoles under solvent-free conditions
Niknam, Khodabakhsh,Mohammadizadeh, Mohammad R.,Mirzaee, Salimeh,Saberi, Dariush
experimental part, p. 663 - 669 (2010/10/19)
Trisubstituted imidazoles have been synthesized in high yields in the presence of silica-bonded S-sulfonic acid as a catalyst. The reaction was carried out at 130 °C under solvent-free conditions. The reaction work-up is simple and the catalyst is easily separated from the products by filtration.
Fluorine containing 2,4,5-triphenylimidazoles
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, (2008/06/13)
Fluorosubstituted benzaldehydes are condensed with anisil and ammonium acetate to yield the corresponding 2-(fluorosubstituted phenyl)-4,5-bis(4-methoxyphenyl)imidazoles. Alternatively fluorosubstituted benzaldehydes are condensed with anisil monoxime and ammonium acetate to yield the corresponding 2-(fluorosubstituted phenyl)-4,5-bis(4-methoxyphenyl)-imidazole-3-oxides which can subsequently be reduced to yield the corresponding 2-(fluorosubstituted phenyl)-4,5-bis(4-methoxyphenyl)imidazoles. These imidazoles have interesting pharmacological properties.
