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Validamycin A undecabenzyl ether is a chemical derivative of the natural product validamycin A, which is a potent antifungal agent produced by the bacterium Streptomyces hygroscopicus. This derivative is characterized by the attachment of eleven benzyl groups to the parent molecule, which can enhance its solubility and potentially its bioavailability. The chemical structure of validamycin A undecabenzyl ether is designed to target the fungal cell wall, specifically by inhibiting the enzyme chitin synthase, which is crucial for the synthesis of chitin, a major component of the fungal cell wall. This inhibition leads to the disruption of the cell wall's integrity, ultimately resulting in the death of the fungal cells. The chemical's unique structure and mechanism of action make it a valuable compound in the development of new antifungal drugs, particularly in the context of increasing resistance to existing antifungal treatments.

73482-11-8

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73482-11-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 73482-11-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,3,4,8 and 2 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 73482-11:
(7*7)+(6*3)+(5*4)+(4*8)+(3*2)+(2*1)+(1*1)=128
128 % 10 = 8
So 73482-11-8 is a valid CAS Registry Number.

73482-11-8Downstream Products

73482-11-8Relevant academic research and scientific papers

Synthetic Studies on Antibiotic Validamycins. Part 11. Synthesis of Validamycin A

Ogawa, Seiichiro,Nose, Taisuke,Ogawa, Takao,Toyokuni, Tatsushi,Iwasawa, Yoshikazu,Suami, Tetsuo

, p. 2369 - 2374 (2007/10/02)

The antibiotic validamycin A (1a) has been synthesized for the first time (as its undeca-O-acetate) by glycosylation of the partially protected derivative (8) of the aglycone, validoxylamine A (2a), with 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl chloride (11), followed by deprotection, thereby establishing the structure previously assigned.The totally O-acetylated derivative (19) of 7-deoxyvalidamycin A has been synthesized in a similar fashion.

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