73485-68-4

Basic information

• Product Name: 2-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)ethanol
• Synonyms: 2-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)ethanol
• CAS NO: 73485-68-4
• Molecular Weight: 460.57
• Mol File: 73485-68-4.mol

Chemical Properties

• CAS DataBase Reference: 2-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)ethanol(73485-68-4)
• EPA Substance Registry System: 2-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)ethanol(73485-68-4)

Safety Data

• Hazardous Substances Data: 73485-68-4(Hazardous Substances Data)

Upstream product

• 56752-57-9 methyl 3,6-anhydro-2-deoxy-4,5-O-isopropylidene-7-O-trityl-D-allo-heptanoate 

Downstream Products

• 73556-57-7 2-(ethoxycarbonylmethyl-hydrazono)-O⁵,O⁶-isopropylidene-O⁸-trityl-D-allo-4,7-anhydro-2,3-dideoxy-octonic acid methyl ester 
• 73485-72-0 methyl 2-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)-3-methoxyacrylate 
• 73556-53-3 methyl 3-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)pyruvate 
• 73485-71-9 methyl 3-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)propionate 
• 73485-70-8 4,7-anhydro-2,3-dideoxy-5,6-O-isopropylidene-8-O-trityl-D-allo-octononitrile 
• 73556-59-9 3-<(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)methyl>-5-carbamoyl-4-hydroxypyrazole 
• 73556-58-8 3-<(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)methyl>-5-methoxycarbonyl-4-hydroxypyrazole 
• 73485-73-1 5-<(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)methyl>-2-thiouracil 
• 73497-76-4 5-<(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)methyl>uracil 
• 73556-54-4 2-<(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)methyl>maleimide 
• 937251-05-3 3,6-anhydro-1,2-dideoxy-4,5-O-isopropylidene-1-(5-phenyl-1H-1,2,3-triazol-1-yl)-7-O-trityl-D-allo-heptitol 
• 937251-04-2 3,6-anhydro-1,2-dideoxy-4,5-O-isopropylidene-1-(4-phenyl-1H-1,2,3-triazol-1-yl)-7-O-trityl-D-allo-heptitol 
• 937251-03-1 3,6-anhydro-1-azido-1,2-dideoxy-4,5-O-isopropylidene-7-O-trityl-D-allo-heptitol 
• 937251-09-7 3,6-anhydro-1,2-dideoxy-4,5-O-isopropylidene-1-[4-(2-pyridinyl)-1H-1,2,3-triazol-1-yl]-7-O-trityl-D-allo-heptitol 

Relevant articles and documents

1,2,3-Triazolylalkylribitol derivatives as nucleoside hydrolase inhibitors

A range of novel 1,2,3-triazolylalkylribitol derivatives were synthesized and evaluated as nucleoside hydrolase inhibitors. The most active compound (11a) has low micromolar potency and is structurally diverse from previously reported nucleoside hydrolase

Synthesis and biochemical evaluation of guanidino-alkyl-ribitol derivatives as nucleoside hydrolase inhibitors

Nucleoside hydrolase (NH) is a key enzyme in the purine salvage pathway. The purine specificity of the IAG-NH from Trypanosoma vivax is at least in part due to cation-π-stacking interactions. Guanidinium ions can be involved in cation-π-stacking interactions, therefore a series of guanidino-alkyl-ribitol derivatives were synthesized in order to examine the binding affinity of these compounds towards the target enzyme. The compounds show moderate to good inhibiting activity towards the IAG-NH from T. vivax.

General Synthesis of Homo-C-nucleosides

Lithium aluminium hydride reduction of methyl (2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)acetate gives 2-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)ethanol. Subsequent tosylation, displacement by cyanide ion, nitrile hydrolysis, and diazom