73485-70-8

Upstream product

• 937251-02-0 3,6-anhydro-2-deoxy-4,5-O-isopropylidene-1-O-(methylsulfonyl)-7-O-trityl-D-allo-heptitol 
• 143-33-9 sodium cyanide 
• 73485-68-4 2-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)ethanol 
• 56752-57-9 methyl 3,6-anhydro-2-deoxy-4,5-O-isopropylidene-7-O-trityl-D-allo-heptanoate 
• 73485-69-5 2-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)ethyl p-toluenesulfonate 
• 151-50-8 potassium cyanide 

Downstream Products

• 73556-54-4 2-<(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)methyl>maleimide 
• 73497-76-4 5-<(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)methyl>uracil 
• 1020107-26-9 1-amino-4,7-anhydro-1,2,3-trideoxy-5,6-O-isopropylidene-8-O-trityl-D-allo-octitol 
• 73556-57-7 2-(ethoxycarbonylmethyl-hydrazono)-O⁵,O⁶-isopropylidene-O⁸-trityl-D-allo-4,7-anhydro-2,3-dideoxy-octonic acid methyl ester 
• 73485-72-0 methyl 2-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)-3-methoxyacrylate 
• 73556-53-3 methyl 3-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)pyruvate 
• 73485-71-9 methyl 3-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)propionate 
• 73556-59-9 3-<(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)methyl>-5-carbamoyl-4-hydroxypyrazole 
• 73556-58-8 3-<(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)methyl>-5-methoxycarbonyl-4-hydroxypyrazole 
• 73485-73-1 5-<(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)methyl>-2-thiouracil 

Relevant academic research and scientific papers

Synthesis and biochemical evaluation of guanidino-alkyl-ribitol derivatives as nucleoside hydrolase inhibitors

Nucleoside hydrolase (NH) is a key enzyme in the purine salvage pathway. The purine specificity of the IAG-NH from Trypanosoma vivax is at least in part due to cation-π-stacking interactions. Guanidinium ions can be involved in cation-π-stacking interactions, therefore a series of guanidino-alkyl-ribitol derivatives were synthesized in order to examine the binding affinity of these compounds towards the target enzyme. The compounds show moderate to good inhibiting activity towards the IAG-NH from T. vivax.

General Synthesis of Homo-C-nucleosides

Lithium aluminium hydride reduction of methyl (2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)acetate gives 2-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)ethanol. Subsequent tosylation, displacement by cyanide ion, nitrile hydrolysis, and diazom