73486-85-8 Usage
Pharmacological Properties
Selective agonist for the alpha-7 nicotinic acetylcholine receptor (α7nAChR)
α7nAChR is a ligand-gated ion channel found in the central nervous system
Therapeutic Applications
Studied for potential use in neurological and psychiatric disorders
Alzheimer's disease
Schizophrenia
Cognitive deficits
Specific Activity
Acts specifically on α7nAChR
Drug Development Target
Considered for further research and drug development due to its potential therapeutic effects
Check Digit Verification of cas no
The CAS Registry Mumber 73486-85-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,3,4,8 and 6 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 73486-85:
(7*7)+(6*3)+(5*4)+(4*8)+(3*6)+(2*8)+(1*5)=158
158 % 10 = 8
So 73486-85-8 is a valid CAS Registry Number.
73486-85-8Relevant academic research and scientific papers
Ruthenium-catalyzed /V-alkylation of amines and sulfonamides using borrowing hydrogen methodology
Hamid, M. Haniti S. A.,Allen, C. Liana,Lamb, Gareth W.,Maxwell, Aoife C.,Maytum, Hannah C.,et al.
supporting information; experimental part, p. 1766 - 1774 (2009/07/25)
The alkylation of amines by alcohols has been achieved using 0.5 mol percent [Ru(p-cymene)CI2]2 with the bidentate phosphines dppf or DPEphos as the catalyst. Primary amines have been converted into secondary amines, and secondary amines into tertiary amines, including the syntheses of Piribedil, Tripelennamine, and Chlorpheniramine. A/-Heterocyclization reactions of primary amines are reported, as well as alkylation reactions of primary sulfonamides. Secondary alcohols requiremore forcing conditions than primary alcohols but are still effective a lkylating agents in the presence of this catalyst.
