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• 482-36-0 Hyperoside 

Relevant academic research and scientific papers

Cytotoxic activities of flavonoid glycoside acetates from Consolida oliveriana

The flavonoids kaempferol, quercetin, trifolin, hyperoside 2″- and 6″- acetates, 7-glucotrifolin, biorobin and robinin were isolated from the aerial parts of Consolida oliveriana. Their derivatives kaempferol tetraacetate, quercetin pentaacetate, trifolin heptaacetate and hyperoside octaacetate exhibited significant cytotoxicity in vitro against three human cell lines HL-60, U937 and SK-MEL-1 while hyperoside 2″-acetate, hyperoside-6″-acetate, glucotrifolin decaacetate and heptamethyltrifolin were inactive. Georg Thieme Verlag KG Stuttgart.

Direct stereochemical assignmenet of hexose and pentose residues in flavonoid O-glycosides by fast atom bombardment and electrospray ionization mass spectrometry

Mass spectrometric methods have been developed which allow the direct stereochemical assignment of terminal monosaccharide residues in flavonoid O-glycosides without the need for chemical hydrolysis. Standards containing a glucose, galactose, mannose, xylose, arabinose or apiose residue were examined because these monosaccharides are by far the most commonly encountered in flavonoid glycosides. Following acetylation, the major peracetylated sugar related fragments, generated by fast atom bombardment (FAB) or electrospray ionization (ESI), were selected for collisional activation employing a broad range of collision energies. Both FAB and ESI proved to be useful as ionization techniques. Stereoselective fragmentation was achieved and allowed us clearly to differentiate and characterize isomeric monosaccharide residues. The method developed was successfully applied to an unknown flavonoid containing a terminal pentose and hexose residue which was isolated from Farsetia aegyptia. Copyright