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Hyperoside Hypericumperforatum Extact
Cas No: 482-36-0
USD $ 8.0-10.0 / Kilogram 1 Kilogram 4000 Metric Ton/Day Kono Chem Co.,Ltd Contact Supplier
Hyperoside
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No Data 20 Milligram 20 Gram/Day Chengdu Alfa Biotechnology Co.,Ltd. Contact Supplier
Hyperoside Manufacturer/High quality/Best price/In stock
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USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
Hyperoside
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No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
High Content Natural Extract Hyperoside HACCP manufacturer
Cas No: 482-36-0
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[[(3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-1-benzopyran-4-one
Cas No: 482-36-0
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
Hyperoside Hypericumperforatum Extact CAS NO.482-36-0
Cas No: 482-36-0
USD $ 8.0-10.0 / Kilogram 1 Kilogram 1000 Kilogram/Month Xi'an Julong Bio-Tech Co., Ltd. Contact Supplier
Hyperoside 482-36-0
Cas No: 482-36-0
USD $ 500.0-500.0 / Metric Ton 1 Metric Ton 1 Metric Ton/Day Henan Tianfu Chemical Co., Ltd. Contact Supplier
Pharmaceutical Grade CAS 482-36-0 with competitive price
Cas No: 482-36-0
USD $ 139.0-210.0 / Kilogram 1 Kilogram 1000 Kilogram/Day Zhuozhou Wenxi import and Export Co., Ltd Contact Supplier
BLOOM TECH Advanced API/Technology support Hyperoside CAS 482-36-0
Cas No: 482-36-0
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482-36-0 Usage

Natural occurance

Hyperoside is an important natural substance extracted from the dried flowers of the mallow leaves. It is a pale yellow needle-like crystal, and soluble in ethanol, methanol, acetone and pyridine, and stable usually. It could react with hydrochloric acid-magnesium powder to generate cherry red material. Hyperoside is a flavonol glycoside compound. Hyperoside also has a strong role in inhibiting oogidity reductase, and may be beneficial to the prevention of diabetic cataracts.

Definition

ChEBI: A quercetin O-glycoside that is quercetin with a beta-D-galactosyl residue attached at position 3. Isolated from Artemisia capillaris, it exhibits hepatoprotective activity.

Pharmacological effects

Pharmacological effects Hyperoside has a significant local analgesic effect with no dependence. Its analgesic effect is weaker than morphine, stronger than aspirin, and it is a new type of local analgesic drug. The drug has shown a good protective effect on myocardial ischemia and reperfusion, cerebral ischemia and reperfusion, cerebral infarction. Hypericin has a significant anti-inflammatory effect: rats implanted wool ball, intraperitoneal injection for 7 days with 20mg/Kg daily, significantly inhibiting the inflammatory process. The drug has a strong cough effect. Hyperoside also has a strong role in inhibiting oogidity reductase, and may be beneficial to the prevention of diabetic cataracts.

Extraction

1.? According to Zhongcheng Ke and others, the volume fraction of ethanol, the ratio of material to liquid and the extraction time were independent variables, the extraction rate of hyperoside was the dependent variable, Through the regression of the independent variables and the dependent variables, extraction technology is screened by response surface method predict the best extraction conditions. The results showed that the extraction process was 11.0 times the amount of 77.6% ethanol, and twice with each for 2.7 h. 2.? According to Zhuoheng Li and others, taking ethanol concentration, ethanol addition factor, extraction temperature and extraction times as the influencing factors, using the extraction rate of hyperoside as an index, the orthogonal experiment was used to optimize the optimum conditions of hyperoside ethanol extraction. The optimum extraction process is 20 times the amount of 60% ethanol, and 4 times at 90 ℃ with each for 2 h. The method is simple, accurate and reproducible.

Synthetic method

Hyperoside is a natural extract and can also be synthesized now. For the synthesis process, re-read the relevant literature to add. Rutin was used as raw material to obtain hyperoside by benzylation, acid hydrolysis, glycoside condensation through phase transfer catalyzing, deacetylation and debenzylation.

Chemical Properties

Yellow Solid

Uses

A major flavonoid in apple peels; a bioactive constituent of apple peels

Abstract

Hyperoside is an active ingredient of traditional Chinese medicine extracted from Hypericum perforatum. Modern pharmacological studies have shown that it has a strong analgesic effect, and it could protect the heart, brain, liver, anti-myocardial hypoxia damage and protect cerebral ischemic injury. In recent years, the development of hypericin for the treatment of depression, hepatitis B and other diseases has become a hotspot both in domestic and foreign research.
InChI:InChI=1/C21H20O12/c22-6-13-15(27)17(29)18(30)21(32-13)33-20-16(28)14-11(26)4-8(23)5-12(14)31-19(20)7-1-2-9(24)10(25)3-7/h1-5,13,15,17-18,21-27,29-30H,6H2/t13-,15-,17+,18-,21?/m1/s1

482-36-0 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma-Aldrich (00180585)  Hyperoside  primary pharmaceutical reference standard 482-36-0 00180585-25MG 4,894.11CNY Detail
USP (1335202)  Hyperoside  United States Pharmacopeia (USP) Reference Standard 482-36-0 1335202-50MG 25,529.40CNY Detail

482-36-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name quercetin 3-O-β-D-galactopyranoside

1.2 Other means of identification

Product number -
Other names hyperozide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:482-36-0 SDS

482-36-0Synthetic route

3-O-(2'',3'',4'',6''-tetra-O-acetyl-β-D-galactopyranosyl)-3',4',5,7-tetrahydroxyflavonol
161126-00-7

3-O-(2'',3'',4'',6''-tetra-O-acetyl-β-D-galactopyranosyl)-3',4',5,7-tetrahydroxyflavonol

Hyperoside
482-36-0

Hyperoside

Conditions
ConditionsYield
With sodium methylate In methanol at 20℃; for 0.5h;87%
With sodium methylate In methanol at 20℃; for 1h;81%
With methanol; sodium methylate In ethyl acetate at 20℃; for 0.5h;75%
With methanol; sodium methylate
Stage #1: 3-O-(2'',3'',4'',6''-tetra-O-acetyl-β-D-galactopyranosyl)-3',4',5,7-tetrahydroxyflavonol With sodium methylate In methanol at 20℃; for 1.5h;
Stage #2: In methanol
quercetin-3-O-(2”-galloyl)-β-D-galactopyranoside
53209-27-1, 69624-79-9

quercetin-3-O-(2”-galloyl)-β-D-galactopyranoside

A

Hyperoside
482-36-0

Hyperoside

B

3,4,5-trihydroxybenzoic acid
149-91-7

3,4,5-trihydroxybenzoic acid

Conditions
ConditionsYield
With tannase In water at 37℃; for 2h;
quercetin 3-O-α-L-rhamnopyranosyl(1->2)-β-D-galactopyranoside

quercetin 3-O-α-L-rhamnopyranosyl(1->2)-β-D-galactopyranoside

Hyperoside
482-36-0

Hyperoside

Conditions
ConditionsYield
With formic acid; cyclohexanol for 20h; Heating;
quercetin-3-O-(6-O-galloyl)-β-gallcopyranoside
53171-28-1, 56316-75-7

quercetin-3-O-(6-O-galloyl)-β-gallcopyranoside

Hyperoside
482-36-0

Hyperoside

Conditions
ConditionsYield
With sodium carbonate In methanol; dimethyl sulfoxide at 40℃;28.5 mg
quercetol
117-39-5

quercetol

alkaline solution

alkaline solution

Hyperoside
482-36-0

Hyperoside

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 37 percent / 0.17 h / 180 °C
2: 31 percent / K2CO3 / dimethylformamide / 10 h / 20 °C
3: 79 percent / hydrogen / Pd/C / ethanol / 24 h / 25 °C
4: 81 percent / NaOMe / methanol / 1 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: 0.08 h / 180 °C
2: K2CO3 / dimethylformamide
3: H2 / Pd/C
4: MeONa; MeOH
View Scheme
2-(2,2-diphenylbenzo[1,3]dioxol-5-yl)-3,5,7-trihydroxychromen-4-one
357194-03-7

2-(2,2-diphenylbenzo[1,3]dioxol-5-yl)-3,5,7-trihydroxychromen-4-one

Hyperoside
482-36-0

Hyperoside

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 31 percent / K2CO3 / dimethylformamide / 10 h / 20 °C
2: 79 percent / hydrogen / Pd/C / ethanol / 24 h / 25 °C
3: 81 percent / NaOMe / methanol / 1 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: K2CO3 / dimethylformamide
2: H2 / Pd/C
3: MeONa; MeOH
View Scheme
2-(2,2-diphenylbenzo[d][1,3]dioxol-5-yl)-5,7-dihydroxy-3-(2,3,4,6-tetraacetyl-β-D-galactopyranosyl)-4H-chromen-4-one
742062-20-0

2-(2,2-diphenylbenzo[d][1,3]dioxol-5-yl)-5,7-dihydroxy-3-(2,3,4,6-tetraacetyl-β-D-galactopyranosyl)-4H-chromen-4-one

Hyperoside
482-36-0

Hyperoside

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 79 percent / hydrogen / Pd/C / ethanol / 24 h / 25 °C
2: 81 percent / NaOMe / methanol / 1 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: H2 / Pd/C
2: MeONa; MeOH
View Scheme
Hyperoside
482-36-0

Hyperoside

A

D-Galactose
10257-28-0

D-Galactose

B

quercetol
117-39-5

quercetol

Conditions
ConditionsYield
With sulfuric acid at 100℃; for 1h;A n/a
B 68%
With grape snail enzymes
With rhamnodiastase
Hyperoside
482-36-0

Hyperoside

A

D-Galactose
59-23-4

D-Galactose

B

quercetol
117-39-5

quercetol

Conditions
ConditionsYield
With water Acidic conditions;A n/a
B 64%
Acidic conditions;
Acidic aq. solution;
Hyperoside
482-36-0

Hyperoside

quercetol
117-39-5

quercetol

Conditions
ConditionsYield
Acidic conditions;63.3%
Acid hydrolysis;
With hydrogenchloride In water for 0.5h; Reflux;
Hyperoside
482-36-0

Hyperoside

methanol
67-56-1

methanol

methyl α-L-rhamnosyl-(1->4)-O-β-D-glucopyranosyl-(1->6)-(α and β)-D-glucopyranoside
109606-00-0

methyl α-L-rhamnosyl-(1->4)-O-β-D-glucopyranosyl-(1->6)-(α and β)-D-glucopyranoside

Conditions
ConditionsYield
With 2,6-dimethylpyridine; lithium iodide In methanol; ethanol for 17h; Heating;
Hyperoside
482-36-0

Hyperoside

acetic anhydride
108-24-7

acetic anhydride

hyperoside octaacetate
73489-99-3

hyperoside octaacetate

Conditions
ConditionsYield
With pyridine at 20℃;
With pyridine at 20℃;
Hyperoside
482-36-0

Hyperoside

D-Galactose
10257-28-0

D-Galactose

Conditions
ConditionsYield
Acid hydrolysis;
With hydrogenchloride; water at 90℃; for 1h;
Hyperoside
482-36-0

Hyperoside

A

β-D-galactopyranoside
7296-64-2

β-D-galactopyranoside

B

quercetol
117-39-5

quercetol

Conditions
ConditionsYield
Stage #1: Hyperoside With sulfuric acid; water In methanol at 60℃;
Stage #2: With sodium hydroxide In methanol
Hyperoside
482-36-0

Hyperoside

D-Galactose
59-23-4

D-Galactose

Conditions
ConditionsYield
With hydrogenchloride In methanol at 100℃; for 2h;

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