73496-29-4

Usage

Type of compound

Fluorinated quinoline derivative

Contains

Two hydroxyl groups

Subtype of compound

Phenolic compound

Applications

Pharmaceutical industry (synthesis of drugs and bioactive compounds)

Advantages

Enhanced bioactivity and metabolic stability due to the presence of fluorine atoms

Use

Building block in organic synthesis for the preparation of diverse compounds

Value

Valuable chemical in the fields of medicinal and organic chemistry.

InChI:InChI=1/C10H6F3NO2/c11-10(12,13)7-4-9(16)14-8-3-5(15)1-2-6(7)8/h1-4,15H,(H,14,16)

Upstream product

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Relevant academic research and scientific papers

The indium(III) chloride-catalyzed von Pechmann reaction: A simple and effective procedure for the synthesis of 4-substituted coumarins

Indium(III) chloride is used as an efficient catalyst in the von Pechmann condensation of phenols with β-ketoesters leading to the formation of coumarin derivatives in excellent yields with good purity.

Synthesis and Chemistry of 7-Amino-4-(trifluoromethyl)coumarin and Its Amino Acid and Peptide Derivatives

The synthesis and purification of 7-amino-4-(trifluoromethyl)coumarin, a novel fluorescent marker for the sensitive detection of proteinases, were investigated.Two byproducts, 7-hydroxy-4-(trifluoromethyl-2-quinolone and 2-ethoxy-7-hydroxy-4-(trifluoromethyl)quinoline, were isolated and identified. 7-Methoxy-4-(trifluoromethyl)-2-quinolone was also prepared.Amino acid and peptide derivatives prepared by solution methods using the stepwise approach included 7-(L-leucinamido)-, 7-(D-alanyl-L-leucyl-L-lysinamido)-, 7-(D-valyl-L-leucyl-L-lysinamido)-, and 7-(Nα-Z-glycylglycyl-L-argininamido)-4-(trifluoromethyl)coumarins