73509-11-2Relevant academic research and scientific papers
A New Synthesis of 2,2-Dialkylchromenes: Application to Synthesis of Anti-juvenile Hormones Precocenes I & II
Banerji, A.,Goomer, N. C.
, p. 144 - 146 (2007/10/02)
Enolates of 2-hydroxyacetophenones react with ketones to give cross-condensation products which undergo facile cyclodehydration to 2,2-dialkylchromanones in excellent yield.Reduction of the chromanones with LAH gives chroman-4-ols which on dehydration using p-toluenesulphonic acid give 2,2-dialkylchromenes.The above synthetic scheme has been successfully utilised for the synthesis of anti-juvenile hormones, precocene-I (7-methoxy-2,2-dimethylchromene, Ia) and precocene-II (6,7-dimethoxy-2,2-dimethylchromene, Ib).
