735283-72-4

Downstream Products

• 735286-95-0 (E)-3-[4-({1-[1-({1-[3-cyclohexyl-2-furan-3-yl-1-(2-morpholin-4-yl-2-oxo-ethyl)-1H-indole-6-yl]-methanoyl}-amino)-cyclobutyl]-methanoyl}-amino)-phenyl]-acrylic acid 
• 735285-97-9 3-cyclohexyl-2-furan-3-yl-1-(2-morpholin-4-yl-2-thioxo-ethyl)-1H-indole-6-carboxylic acid 
• 1422251-74-8 C₂₉H₃₆N₄O₆S 
• 1422251-71-5 C₃₁H₃₄N₄O₆S 
• 735284-44-3 C₂₈H₃₃N₃O₆S 
• 735284-19-2 C₃₁H₃₃N₃O₆S 
• 1422251-73-7 C₂₇H₃₄N₄O₆S 
• 735284-20-5 C₂₆H₃₁N₃O₆S 
• 735284-21-6 C₃₂H₃₅N₃O₆S 
• 1422251-70-4 C₂₉H₃₇N₃O₆S 
• 735284-34-1 C₃₂H₃₅N₃O₆S 
• 735284-25-0 C₃₅H₃₅N₃O₆S 

Relevant academic research and scientific papers

N-Acetamideindolecarboxylic acid allosteric 'finger-loop' inhibitors of the hepatitis C virus NS5B polymerase: discovery and initial optimization studies

SAR studies at the N1-position of allosteric indole-based HCV NS5B inhibitors has led to the discovery of acetamide derivatives with good cellular potency in subgenomic replicons (EC50 200 nM). This class of inhibitors displayed improved physicochemical properties and favorable ADME-PK profiles over previously described analogs in this class.

VIRAL POLYMERASE INHIBITORS

An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula (I): wherein wherein A, B, R2, R3, L, M1, M2, M3, M4, Y1, Y0, Z and Sp are as defined in claim 1, or a salt thereof, as an inhibitor of HCV NS5B polymerase.