3-cyclohexyl-2-furan-3-yl-1-(2-morpholin-4-yl-2-oxo-ethyl)-1H-indole-6-carboxylic acid

Base Information

• Chemical Name: 3-cyclohexyl-2-furan-3-yl-1-(2-morpholin-4-yl-2-oxo-ethyl)-1H-indole-6-carboxylic acid
• CAS No.: 735283-72-4
• Molecular Formula: C₂₅H₂₈N₂O₅
• Molecular Weight: 436.508

Synonyms:3-cyclohexyl-2-furan-3-yl-1-(2-morpholin-4-yl-2-oxo-ethyl)-1H-indole-6-carboxylic acid

Chemical Property of 3-cyclohexyl-2-furan-3-yl-1-(2-morpholin-4-yl-2-oxo-ethyl)-1H-indole-6-carboxylic acid

Chemical Property:

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Technology Process of 3-cyclohexyl-2-furan-3-yl-1-(2-morpholin-4-yl-2-oxo-ethyl)-1H-indole-6-carboxylic acid

There total 1 articles about 3-cyclohexyl-2-furan-3-yl-1-(2-morpholin-4-yl-2-oxo-ethyl)-1H-indole-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

methyl 3-cyclohexyl-2-furan-3-yl-1-(2-morpholin-4-yl-2-oxo-ethyl)-1H-indole-6-carboxylate → 3-cyclohexyl-2-furan-3-yl-1-(2-morpholin-4-yl-2-oxo-ethyl)-1H-indole-6-carboxylic acid (735283-72-4)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; at 50 ℃; for 3.5h;

Reference yield: 52.0%

3-cyclohexyl-2-furan-3-yl-1-(2-morpholin-4-yl-2-oxo-ethyl)-1H-indole-6-carboxylic acid (735283-72-4) + N,N-dimethylsulfamide (3984-14-3) → C27H34N4O6S (1422251-73-7)

Guidance literature:

With hydrogenchloride; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 48h; Inert atmosphere;

DOI:10.1139/cjc-2012-0319

Reference yield:

3-cyclohexyl-2-furan-3-yl-1-(2-morpholin-4-yl-2-oxo-ethyl)-1H-indole-6-carboxylic acid (735283-72-4) → 3-cyclohexyl-2-furan-3-yl-1-(2-morpholin-4-yl-2-thioxo-ethyl)-1H-indole-6-carboxylic acid (735285-97-9)

Guidance literature:

With phosphorous (V) sulfide; In tetrahydrofuran; at 50 ℃; for 17h;

Downstream raw materials:

(E)-3-[4-({1-[1-({1-[3-cyclohexyl-2-furan-3-yl-1-(2-morpholin-4-yl-2-oxo-ethyl)-1H-indole-6-yl]-methanoyl}-amino)-cyclobutyl]-methanoyl}-amino)-phenyl]-acrylic acid

3-cyclohexyl-2-furan-3-yl-1-(2-morpholin-4-yl-2-thioxo-ethyl)-1H-indole-6-carboxylic acid

C₃₅H₃₅N₃O₆S

C₃₂H₃₅N₃O₆S

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