73548-14-8

Usage

Uses

Used in Organic Synthesis:
N-(naphthalen-1-yl)-2-phenylacetamide is used as a building block in organic synthesis for the creation of various pharmaceuticals and agrochemicals. Its structural flexibility and diverse reactivity make it a valuable component in the synthesis of complex organic molecules.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, N-(naphthalen-1-yl)-2-phenylacetamide is employed as a building block for the development of new drugs. Its unique structure allows for the design of molecules with specific therapeutic properties, contributing to the advancement of pharmaceutical research.
Used in Drug Development:
N-(naphthalen-1-yl)-2-phenylacetamide has potential applications in the development of new drugs due to its structural characteristics and reactivity. It can be used to create molecules with novel therapeutic effects, enhancing the range of treatments available for various medical conditions.
Used in Material Science:
N-(naphthalen-1-yl)-2-phenylacetamide also has potential uses in material science, where its structural properties can be leveraged to develop new materials with specific characteristics. This can include applications in areas such as coatings, adhesives, or other industrial materials that require unique properties.
Safety Precautions:
Due to potential hazards associated with the handling and use of N-(naphthalen-1-yl)-2-phenylacetamide, it is crucial to follow proper safety protocols. This includes using appropriate personal protective equipment, handling the compound in a well-ventilated area, and disposing of it according to local regulations and guidelines.

Upstream product

• 103-82-2 phenylacetic acid 
• 134-32-7 1-amino-naphthalene 
• 103-80-0 phenylacetyl chloride 
• 260783-80-0 N,N,N--trimethyl--1--phenylmethanaminium trifluoromethanesulfonate 
• 86-57-7 1-Nitronaphthalene 
• 13939-06-5 molybdenum hexacarbonyl 
• 86-84-0 1-Naphthyl isocyanate 
• 6921-34-2 benzylmagnesium chloride 

Downstream Products

• 1046787-09-0 N-(naphthalen-1-yl)-2-oxo-2-phenylacetamide 
• 65016-19-5 N-(naphthalen-1-yl)-2-phenylacrylamide 
• 923603-66-1 3,3-dimethyl-N-(2-phenylacetyl-naphthalen-1-yl)-butyramide 
• 923603-65-0 1-(1-aminonaphthalen-2-yl)-2-phenylethanone 
• 115917-69-6 N,N'-di-[1]naphthyl-2-phenyl-acetamidine 

Relevant academic research and scientific papers

Method for click construction of amido bond by using pyrimidine condensing agent and application of amido bond in synthesis of amide and polypeptide

The invention discloses a method for click construction of an amido bond by using a pyrimidine condensing agent and an application of the amido bond in synthesis of amide and polypeptide. The amido bond construction method comprises the following steps: adding an organic solvent dissolved with organic alkali into a carboxylic acid component and an amine component, stirring for reaction, adding an organic solvent dissolved with a pyrimidine condensing agent, continuously stirring for reaction, concentrating, separating and purifying to obtain an amide or polypeptide product. According to the amido bond construction method, the use amount of the condensing agent is small, and the condensing agent is safe, odorless and easy to store and has good atom economy. The amido bond construction reaction time is only several seconds to ten minutes, and the amide or polypeptide synthesis time is greatly shortened. Besides, the amido bond construction reaction can also be quickly carried out in an organic phase-water phase biphasic system and in the organic phase-water phase biphasic system under the condition that alkali is not added, so that a mild and feasible path is provided for the amido bond construction reaction in an alkali-sensitive biological system.

NDTP Mediated Direct Rapid Amide and Peptide Synthesis without Epimerization

Herein, we explored an unprecedented mild, nonirritating, conveniently available, and recyclable coupling reagent NDTP, which could activate the carboxylic acids via acyl thiocyanide and enable the rapid amide and peptide synthesis at very mild conditions

Palladium Catalyzed Aminocarbonylation of Benzylic Ammonium Triflates with Nitroarenes: Synthesis of Phenylacetamides

A palladium catalyzed reductive aminocarbonylation of benzylic ammonium triflates with nitroarenes for the synthesis of phenylacetamides was developed. Using Pd(acac)2/DPPF catalyst system, a range of different substituted phenylacetamides were prepared in moderate to good yields from benzylic ammonium triflates and nitroarenes through Csp3?N bond cleavage. A variety of alkyl, aryl, and halide substituents on both substrates can be used, and many useful functional groups can be tolerated. (Figure presented.).

Carboxyl activation of 2-mercapto-4,6-dimethylpyrimidine through n-acyl-4,6-dimethylpyrimidine-2-thione: A chemical and spectrophotometric investigation

2-Mercapto-4,6-dimethylpyrimidine, as effective carboxyl activating group, has been successfully proved by converting it into respective acyl derivatives and the subsequent conversion to the amides and esters respectively using amines, amino alcohols and alcohols. The aminolysis and esterification were monitored chemically and spectrophotometrically. This paved way to establish that the above mercaptopyrimidine derivative is an efficient carboxyl activating group applicable in solid phase peptide synthesis.

A straightforward synthesis of N-monosubstituted α-keto amides via aerobic benzylic oxidation of amides

An efficient sodium bicarbonate promoted aerobic oxidation reaction to prepare N-monosubstituted α-keto amides in the presence of n-tetrabutylammonium hydrogensulfate (TBAHS) was described. This reaction provides a very simple and convenient synthetic route to N-monosubstituted α-keto amides from easily available aryl- or heteroarylacetamides in good to high yields without using toxic reagents and harsh conditions.

Triethyl phosphite-p-dimethylaminopyridine, a new reagent for direct syntheses of amides from aliphatic carboxylic acids and amines

Various amides have been prepared with high to moderate yields from the corresponding aliphatic carboxylic acids and amines using triethyl phosphite-p-dimethylaminopyridine as a new reagent and pyridine as solvent, at 100-110°C, for 12 hours.