73549-66-3

Upstream product

• 4916-26-1 (Z)-<1,2-bis(methoxycarbonyl)vinyl>aminotoluene 
• 100-52-7 benzaldehyde 
• 889-31-6 5,5-dimethyl-3-benzylamino-2-cyclohexen-1-one 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 100-46-9 benzylamine 

Relevant academic research and scientific papers

Cu catalyzed cross-dehydrogenative coupling reaction for the synthesis of 3-hydroxy-2-pyrrolidinones

A new convenient strategy for the synthesis of 3-hydroxy-2-pyrrolidinone derivatives featuring regioselective C–C coupling has been developed. This is a Cu (II) catalyzed cross dehydrogenative coupling (CDC) involving enamino-ketones of benzyl amines and di-alkyl acetylenedicarboxylate, followed by cyclization by primary amines. TBHP (tert-butyl hydroperoxide) has been used as the oxidant to promote the coupling protocol. This synthetic route principally demonstrates the scope of CDC reaction and also applicable to gram-scale synthesis.