73552-34-8Relevant academic research and scientific papers
N-Heterocyclic Carbene-Catalyzed Formal [3+3] Annulation of Alkynyl Acylazoliums for the Synthesis of Benzofuro[3,2- b]pyridin-2-ones
Wang, Xiaoxue,Shao, Yuebo,Zhang, Simiao,Lu, Tao,Du, Ding
, p. 12336 - 12343 (2021/08/24)
Through β-activation of alkynoic acid esters with N-heterocyclic carbene catalysis, a formal [3+3] annulation of alkynyl acylazoliums with indolin-3-ones has been developed for the rapid construction of structurally interesting benzofuro[3,2-b]pyridin-2-ones with potential bioactivities. This protocol provides a highly efficient and simple method for the synthesis of the target molecules under mild reaction conditions with a wide substrate scope and excellent chemoselectivity. The synthetic utility of this protocol was also demonstrated by the versatile late-stage modifications.
Method for synthesizing 1,2-dihydrobenzofuranopyridine compound
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Paragraph 0049-0053; 0077, (2021/03/31)
The invention provides a method for synthesizing 1, 2-dihydrobenzofuranopyridine, and a catalytic system used in the method is metal copper and a diphosphine ligand. The reaction can be carried out under the following conditions: the temperature is 60 DEG
Copper-Catalyzed Alkynylation/Cyclization/Isomerization Cascade for Synthesis of 1,2-Dihydrobenzofuro[3,2- b]pyridines and Benzofuro[3,2- b]pyridines
Xie, Huan-Ping,Sun, Lei,Wu, Bo,Zhou, Yong-Gui
, p. 15498 - 15507 (2019/11/28)
An efficient copper-catalyzed cascade alkynylation/cyclization/isomerization reaction of aurone-derived azadienes with terminal alkynes has been developed, giving a series of 1,2-dihydrobenzofuro[3,2-b]pyridines with excellent yields. The obtained 1,2-dih
2,4-Diaryl benzofuro[3,2-b]pyridine derivatives: Design, synthesis, and evaluation of topoisomerase inhibitory activity and cytotoxicity
Thapa, Pritam,Jahng, Yurngdong,Park, Pil-Hoon,Jee, Jun-Goo,Kwon, Youngjoo,Lee, Eung-Seok
, p. 3073 - 3082 (2014/01/06)
Designed and synthesized twenty-four 2,4-diaryl benzofuro[3,2-b]pyridine derivatives were evaluated for topoisomerase I and II inhibitory activities as well as cytotoxicities against several human cancer cell lines. Various aryl groups such as phenyl, 2-
