7357-12-2

Usage

Uses

Used in Organic Synthesis:
(1E)-1-(5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)ETHANONE OXIME is used as a reagent in organic synthesis for the formation of heterocycles. Its unique structure allows it to participate in various chemical reactions, contributing to the creation of complex organic molecules.
Used in Pharmaceutical Applications:
In the pharmaceutical industry, (1E)-1-(5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)ETHANONE OXIME is studied for its potential medicinal properties. It is considered as a candidate for anti-inflammatory agents due to its chemical structure and reactivity, which may offer therapeutic benefits in treating inflammation-related conditions.
Used in Chemical Research:
(1E)-1-(5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)ETHANONE OXIME is also utilized in chemical research to explore its synthesis, properties, and potential applications. Its study contributes to the advancement of organic chemistry, providing insights into new methods and applications for this versatile compound.

InChI:InChI=1/C12H15NO/c1-9(13-14)11-7-6-10-4-2-3-5-12(10)8-11/h6-8,14H,2-5H2,1H3/b13-9+

Upstream product

• 774-55-0 6-Acetyl-1,2,3,4-tetrahydronaphthalene 

Downstream Products

• 50878-03-0 N-(5,6,7,8-tetrahydronaphth-2-yl)acetamide 
• 886-66-8 1,4-diphenyl-1,3-butadiyne 
• 1260236-32-5 N-[1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl]acetamide 
• 1532520-70-9 C₂₈H₂₅NO 
• 1333120-02-7 4-phenyl-2,6-bis(5,6,7,8-tetrahydronaphthalen-2-yl)pyridine 
• 627526-54-9 4,4,5,5-tetramethyl-2-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,2-dioxaborolane 

Relevant academic research and scientific papers

Transformations of Aryl Ketones via Ligand-Promoted C?C Bond Activation

The coupling of aromatic electrophiles (aryl halides, aryl ethers, aryl acids, aryl nitriles etc.) with nucleophiles is a core methodology for the synthesis of aryl compounds. Transformations of aryl ketones in an analogous manner via carbon–carbon bond activation could greatly expand the toolbox for the synthesis of aryl compounds due to the abundance of aryl ketones. An exploratory study of this approach is typically based on carbon–carbon cleavage triggered by ring-strain release and chelation assistance, and the products are also limited to a specific structural motif. Here we report a ligand-promoted β-carbon elimination strategy to activate the carbon–carbon bonds, which results in a range of transformations of aryl ketones, leading to useful aryl borates, and also to biaryls, aryl nitriles, and aryl alkenes. The use of a pyridine-oxazoline ligand is crucial for this catalytic transformation. A gram-scale borylation reaction of an aryl ketone via a simple one-pot operation is reported. The potential utility of this strategy is also demonstrated by the late-stage diversification of drug molecules probenecid, adapalene, and desoxyestrone, the fragrance tonalid as well as the natural product apocynin.

TETRAZOLINONE COMPOUND AND USE THEREOF

The compound represented by formula (1): wherein R4 and R5 each represents a hydrogen atom, a halogen atom, or a C1-C3 alkyl group; R6 represents a C1-C4 alkyl group, a C3-C6 cycloalkyl group, or the like; R7, R8, and R9 each represents a hydrogen atom, a halogen atom, or the like; R10 represents a C1-C3 alkyl group, or the like; R13 represents a C1-C3 alkyl group, or the like; and Q represents a phenyl group, or the like; has an excellent control effect on pests.

Synthesis of chiral α-amino tertiary boronic esters by enantioselective hydroboration of α-arylenamides

The rhodium-catalyzed asymmetric hydroboration of α-arylenamides with BI-DIME as the chiral ligand and (Bpin)2 as the reagent yields for the first time a series of α-amino tertiary boronic esters in good yields and excellent enantioselectivities (up to 99% ee).

Modulation of PPAR subtype selectivity. Part 2: Transforming PPARα/γ dual agonist into α selective PPAR agonist through bioisosteric modification

A novel series of oxime containing benzyl-1,3-dioxane-r-2-carboxylic acid derivatives (6a-k) were designed as selective PPARα agonists, through bioisosteric modification in the lipophilic tail region of PPARα/γ dual agonist. Some of the test compounds (6a

Human glucagon receptor antagonists with thiazole cores. A novel series with superior pharmacokinetic properties

The aim of the work presented here was to design and synthesize potent human glucagon receptor antagonists with improved pharmacokinetic (PK) properties for development of pharmaceuticals for the treatment of type 2 diabetes. We describe the preparation of compounds with cyclic cores (5-aminothiazoles), their binding affinities for the human glucagon and GIP receptors, as well as affinities for rat, mouse, pig, dog, and monkey glucagon receptors. Generally, the compounds had slightly less glucagon receptor affinity compared to compounds of the previous series, but this was compensated for by much improved PK profiles in both rats and dogs with high oral bioavailabilities and sustained high plasma exposures. The compounds generally showed species selectivity for glucagon receptor binding with poor affinities for the rat, mouse, rabbit, and pig receptors. However, dog and monkey glucagon receptor affinities seem to reflect the human situation. One compound of this series, 18, was tested intravenously in an anesthetized glucagon-challenged monkey model of hyperglucagonaemia and hyperglycaemia and was shown dose-dependently to decrease glycaemia. Further, high plasma exposures and a long plasma half-life (5.2 h) were obtained.

Fungicidal cyclic amides

Cyclic amides, including triazole containing cyclic amides, their N-oxides, agriculturally-suitable salts and compositions, and their methods of use as fungicides.