50878-03-0

Usage

Uses

Used in Chemical Research:
5,6,7,8-Tetrahydronaphthalene-2-yl-acetamide is used as a research compound for studying its chemical properties and potential applications in various fields. 5,6,7,8-TETRAHYDRONAPHTHALENE-2-YL-ACETAMIDE's unique structure and characteristics make it a valuable subject for scientific investigation.
Used in Pharmaceutical Development:
5,6,7,8-Tetrahydronaphthalene-2-yl-acetamide is used as a starting material or intermediate in the synthesis of pharmaceutical compounds. Its potential as a therapeutic agent or as a component in drug formulations is being explored in ongoing research.
Used in Material Science:
5,6,7,8-Tetrahydronaphthalene-2-yl-acetamide is used as a component in the development of new materials with specific properties, such as improved stability or enhanced performance in certain applications. Its role in material science is still under investigation.
Used in Industrial Applications:
5,6,7,8-Tetrahydronaphthalene-2-yl-acetamide is used as a specialty chemical in various industrial processes. Its unique properties may be harnessed for specific applications, such as in the production of coatings, adhesives, or other chemical products. The exact uses in industry are still being explored and may vary depending on the specific context.

InChI:InChI=1/C12H15NO/c1-9(14)13-12-7-6-10-4-2-3-5-11(10)8-12/h6-8H,2-5H2,1H3,(H,13,14)

Upstream product

• 774-55-0 6-Acetyl-1,2,3,4-tetrahydronaphthalene 
• 581-97-5 2-acetylaminonaphthalene 
• 7357-12-2 1-(5,6,7,8-tetrahydro-[2]naphthyl)-ethanone oxime 
• 2217-43-8 6-amino-1,2,3,4-tetrahydronaphthalene 
• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 
• 75-36-5 acetyl chloride 
• 91-17-8 decalin 
• 119-64-2 tetralin 
• 90-15-3 α-naphthol 
• 19353-86-7 6-nitrotetralin 
• 7664-93-9 sulfuric acid 
• 7357-12-2 1-(5,6,7,8-tetrahydronaphthanen-2-yl)ethanone oxime 
• 18312-45-3 propan-2-one O-acetyl oxime 

Downstream Products

• 860183-20-6 2-(3-acetylamino-5,6,7,8-tetrahydro-[2]naphthoyl)-benzoic acid 
• 2217-43-8 6-amino-1,2,3,4-tetrahydronaphthalene 
• 408310-39-4 N-(3-chloroacetyl-5,6,7,8-tetrahydro-[2]naphthyl)-acetamide 
• 3470-53-9 6-amino-1-tetralone 
• 88611-67-0 6-acetamido-1,2,3,4-tetrahydronaphthalen-1-one 
• 854644-84-1 2-(3-acetylamino-5,6,7,8-tetrahydro-[2]naphthylmethyl)-benzoic acid 
• 342043-42-9 2-amino-1-nitro-5,6,7,8-tetrahydronaphthalene 
• 40300-80-9 5,6-diamino-1,2,3,4-tetrahydronaphthalene 
• 56163-17-8 5,6,7,8-tetrahydronaphthalene-2,3-diamine 
• 90401-84-6 6-cyano-1-tetralone 
• 3470-46-0 5-oxo-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid 
• 400759-69-5 6-[(N-acetyl-N-ethyl)amino]-1-tetralone 

Relevant academic research and scientific papers

Nickel-catalyzed regioselective thiolation of anilides with thiols

An efficient method for direct thiolation of anilides with thiols using NiCl2·6H2O as the catalyst is developed. Using this method, the desired products were successfully synthesized in moderate to good yields. Initial mechanistic studies suggest that this reaction proceeds through a radical pathway.

Visible-light-induced Beckmann rearrangement by organic photoredox catalysis

A facile and general strategy for efficient direct conversion of oximes to amides using an inexpensive organic photocatalyst and visible light is described. This radical Beckmann rearrangement can be performed under mild conditions. Various alkyl aryl ketoximes and diaryl ketoximes can be effectively converted into the corresponding amides in excellent yields.

An Electrochemical Beckmann Rearrangement: Traditional Reaction via Modern Radical Mechanism

Abstract: Electrosynthesis as a potential means of introducing heteroatoms into the carbon framework is rarely studied. Herein, the electrochemical Beckmann rearrangement, i. e. the direct electrolysis of ketoximes to amides, is presented for the first time. Using a constant current as the driving force, the reaction can be easily carried out under neutral conditions at room temperature. Based on a series of mechanistic studies, a novel radical Beckmann rearrangement mechanism is proposed. This electrochemical Beckmann rearrangement does not follow the trans-migration rule of the classical Beckmann rearrangement.

COMPOUNDS AND METHODS FOR IDO AND TDO MODULATION, AND INDICATIONS THEREFOR

Disclosed are compounds of Formula (I) and (Ia) or a pharmaceutically acceptable salt, a solvate, a tautomer, a stereoisomer or a deuterated analog thereof, wherein R4, R5, R6, and R7 are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.

COMPOUNDS AND METHODS FOR IDO AND TDO MODULATION, AND INDICATIONS THEREFOR

Disclosed are compounds of Formula I (a) or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein R4, R5, R6, R7, G1, G2 and Ring A are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.

A process for the preparation of the compound naphthylamine of process (by machine translation)

The present invention provides a process for preparing compound naphthylamine process method, characterized in that the polarity of the naphthylamine compound dissolved in a solvent proton gender, added with an auxiliary agent, said assistant agent amount is the quality of the states naphthalene amine compound 0.05 - 0.25 times, in order to Ni as the catalyst, hydrogenation reaction at room temperature, after the reaction, filtration, concentration to obtain a tetrahydronaphthalene compounds, the naphthylamine compound of the formula I as shown in the structural formula: the tetrahydronaphthalene amine structural formula of the compound is shown as formula (II) is shown. The reaction of this invention is completed at room temperature, greatly reduced the production energy consumption. At the same time, the reaction almost in the neutral condition, system conditions apply to acid, alkali, heat sensitive all substrate, wide range of application. In addition, because the reaction of the hydrogen pressure is atmospheric, the need to use a high-pressure autoclave equipment, thereby reducing the safety factor in the production process, and reduces equipment investment, greatly reduce the production cost, and is suitable for large-scale industrial production. (by machine translation)

Exploitation of a Candida antarctica lipase B-catalysed in situ carboxylic acid activation method for the synthesis of acetanilides

An efficient biocatalytic method has been developed which provides acetanilides in good yields which are otherwise inaccessible using Candida antarctica lipase B. The process exploits the enzyme-catalysed synthesis of an acyl donor and its in situ reaction with anilines. The method is potentially useful for the synthesis of bulky acetanilides since amide formation occurs through an active site-independent step.

Human glucagon receptor antagonists with thiazole cores. A novel series with superior pharmacokinetic properties

The aim of the work presented here was to design and synthesize potent human glucagon receptor antagonists with improved pharmacokinetic (PK) properties for development of pharmaceuticals for the treatment of type 2 diabetes. We describe the preparation of compounds with cyclic cores (5-aminothiazoles), their binding affinities for the human glucagon and GIP receptors, as well as affinities for rat, mouse, pig, dog, and monkey glucagon receptors. Generally, the compounds had slightly less glucagon receptor affinity compared to compounds of the previous series, but this was compensated for by much improved PK profiles in both rats and dogs with high oral bioavailabilities and sustained high plasma exposures. The compounds generally showed species selectivity for glucagon receptor binding with poor affinities for the rat, mouse, rabbit, and pig receptors. However, dog and monkey glucagon receptor affinities seem to reflect the human situation. One compound of this series, 18, was tested intravenously in an anesthetized glucagon-challenged monkey model of hyperglucagonaemia and hyperglycaemia and was shown dose-dependently to decrease glycaemia. Further, high plasma exposures and a long plasma half-life (5.2 h) were obtained.

Tricyclic [1,2,4]triazine 1,4-dioxides as hypoxia selective cytotoxins

A series of novel tricyclic triazine-di-N-oxides (TTOs) related to tirapazamine have been designed and prepared. A wide range of structural arrangements with cycloalkyl, oxygen-, and nitrogen-containing saturated rings fused to the triazine core, coupled with various side chains linked to either hemisphere, resulted in TTO analogues that displayed hypoxia-selective cytotoxicity in vitro. Optimal rates of hypoxic metabolism and tissue diffusion coefficients were achieved with fused cycloalkyl rings in combination with both the 3-aminoalkyl or 3-alkyl substituents linked to weakly basic soluble amines. The selection was further refined using pharmacokinetic/pharmacodynamic model predictions of the in vivo hypoxic potency (AUCreq) and selectivity (HCD) with 12 TTO analogues predicted to be active in vivo, subject to the achievement of adequate plasma pharmacokinetics.

TRICYCLIC 1,2,4-TRIAZINE OXIDES AND COMPOSITIONS THEREFROM FOR THERAPEUTIC USE IN CANCER TREATMENTS

The invention relates to novel tricyclic 1,2,4-triazine-1-oxides and novel tricyclic 1,2,4-triazine-1,4-dioxides of formula: (I); and to related analogues, to their preparation, and to their use as hypoxia-selective drugs and radiosensitizers for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.