7357-66-6

Usage

Uses

Used in Organic Synthesis:
N-(5-Bromo-4-methoxy-2-nitrophenyl)acetamide is used as a building block in organic synthesis for the creation of a diverse range of chemical compounds. Its unique structure, which includes a bromine atom and a nitro group, allows for various chemical reactions, facilitating the synthesis of complex organic molecules.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, N-(5-Bromo-4-methoxy-2-nitrophenyl)acetamide is employed as a precursor for the synthesis of pharmaceuticals. Its structural features enable the development of new drugs with potential therapeutic applications, contributing to the advancement of medicine and healthcare.
Used in Agrochemicals:
N-(5-Bromo-4-methoxy-2-nitrophenyl)acetamide is also utilized in the synthesis of agrochemicals, such as pesticides and herbicides. Its chemical properties make it a valuable component in the development of effective and environmentally friendly agricultural products.
Used in Material Science:
In material science, N-(5-Bromo-4-methoxy-2-nitrophenyl)acetamide may be used as a component in the development of new materials with specific properties. Its potential applications in this field could include the creation of polymers with unique characteristics, contributing to the innovation of materials with diverse uses.
Used in Polymer Chemistry:
N-(5-Bromo-4-methoxy-2-nitrophenyl)acetamide holds potential in polymer chemistry, where it can be incorporated into the synthesis of polymers with tailored properties. Its presence in polymer structures may lead to the development of new materials with improved performance in various applications, such as coatings, adhesives, and plastics.

InChI:InChI=1/C9H9BrN2O4/c1-5(13)11-7-3-6(10)9(16-2)4-8(7)12(14)15/h3-4H,1-2H3,(H,11,13)

Upstream product

• 6943-73-3 N-(3-bromo-4-methoxyphenyl)acetamide 
• 51-66-1 4-methoxyacetanilide 
• 19056-41-8 3-bromo-p-anisidine 
• 108-24-7 acetic anhydride 

Downstream Products

• 6943-69-7 5-bromo-4-methoxy-2-nitro-phenylamine 
• 98081-50-6 4-acetamino-5-nitro-2-(3-trifluoromethylphenyloxy)anisole 
• 108447-01-4 4-bromo-5-methoxy-1,2-phenylenediamine 
• 82333-37-7 6-methoxy-4-methyl-8-nitro-5-<3-(trifluoromethyl)phenoxy>quinoline 
• 82333-41-3 8-amino-6-methoxy-4-methyl-5-(3-trifluoromethylphenoxy)quinoline 
• 955995-49-0 4-{N-[4-methoxy-2-nitro-5-(trifluoromethylphenyloxy)]phenylamino}-2-butanone 
• 98081-56-2 4-amino-5-nitro-2-(3-trifluoromethylphenyloxy)anisole 
• 1361026-00-7 4-acetamino-2-(3-fluorophenyloxy)-5-nitro-anisole 
• 158430-70-7 4-acetamino-5-nitro-2-phenyloxyanisole 
• 1628960-41-7 6-methoxy-4-methyl-8-(3-phthalimidopropylamino)-5-phenyloxyquinoline 
• 1628960-36-0 5-(3-fluorophenyloxy)-6-methoxy-4-methyl-8-(3-phthalimidopropylamino)quinoline 
• 158430-73-0 4-amino-5-nitro-2-phenyloxyanisole 
• 82329-71-3 8-amino-6-methoxy-4-methyl-5-phenyloxyquinoline 
• 106363-57-9 8-amino-5-(3-fluorophenyloxy)-6-methoxy-4-methylquinoline 

Relevant academic research and scientific papers

METHODS AND COMPOSITIONS FOR MODULATING SPLICING

Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

Investigation of novel 7,8-disubstituted-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-ones as potent Chk1 inhibitors

The synthesis and structure-activity relationships (SAR) of Chk1 inhibitors based on a 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one core are described. Specifically, an exploration of the 7 and 8 positions on this previously disclosed core afforded compounds with improved enzymatic and cellular potency.

Synthesis and anti-breast cancer activities of substituted quinolines

Promising anti-breast cancer agents derived from substituted quinolines were discovered. The quinolines were readily synthesized in a large scale from a sequence of reactions starting from 4-acetamidoanisole. The Michael addition product was isolated as the reaction intermediate in the ring closing reaction of 4-amino-5-nitro-2-(3-trifluoromethylphenyloxy)anisole with methyl vinyl ketone leading to 6-methoxy-4-methyl-8-nitro-5-(3-trifluoromethylphenyloxy)quinoline (14). The amino function of 8-amino-6-methoxy-4-methyl-5-(3-trifluoromethylphenyloxy)quinoline, prepared from 14, was connected to various side chains via alkylation with N-(3-iodopropyl)phthalimide, Michael addition with acrylonitrile, and reductive amination with various heterocycle carboxaldehydes, such as imidazole-4-carboxaldehyde, thiophene-2-carboxaldehyde, and 2-furaldehyde. Effects of the substituted quinolines on cell viability of T47D breast cancer cells using trypan blue exclusion assay were examined. The results showed that the IC50 value of 6-methoxy-8-[(2-furanylmethyl)amino]-4-methyl-5-(3-trifluoromethylphenyl oxy)quinoline is 16 ± 3 nM, the lowest IC50 out of all the quinolines tested. IC50 values of three other quinolines are in the nanomolar range, a desirable range for pharmacological testing.

COMPOUNDS AFFECTING GAP JUNCTION ACTIVITY

ThThis invention relates to novel quinoline compounds which affect gap junction activity. Also provided are methods of using such compounds and compositions containing the compounds to treat gap junction disorders.

HETEROCYCLIC KINASE INHIBITORS

Compounds having the formula (I) are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Heterocyclic Systems Containing Bridgehead Nitrogen Atom: Part LIV - Synthesis of Thiazolobenzimidazol-3-(2H)-ones

3-Bromo-4-methoxyacetanilide (V) on nitration with fuming nitric acid in the presence of acetic anhydride gives 3-bromo-4-methoxy-6-nitroacetanilide (VI) which on hydrolysis and subsequent reduction of the nitroaniline (IX) followed by the treatment of th