19056-41-8

Usage

Uses

Used in Organic Synthesis:
3-Bromo-4-methoxyaniline is used as a building block in organic synthesis for the creation of various other organic compounds. Its unique structure allows for the formation of a wide range of derivatives, making it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Research:
In pharmaceutical research, 3-Bromo-4-methoxyaniline is utilized as a key intermediate in the development of new drugs. Its chemical properties enable it to be incorporated into the molecular structures of potential therapeutic agents, contributing to the discovery of novel pharmaceuticals.
Used as a Dye Intermediate:
3-Bromo-4-methoxyaniline is also used as a dye intermediate in the production of various dyes. Its chemical structure allows for the creation of dyes with specific color properties, making it an important component in the dye manufacturing process.
Used in Agrochemical Production:
3-BROMO-4-METHOXYANILINE is further employed in the production of agrochemicals, where it serves as a crucial intermediate in the synthesis of various agrochemical products. Its role in this industry is essential for the development of effective and targeted agrochemicals.
Safety Considerations:
Given its moderate toxicity, 3-Bromo-4-methoxyaniline should be handled with care, adhering to proper safety protocols to minimize potential health risks during its use in various applications.

InChI:InChI=1/C7H8BrNO/c1-10-7-3-2-5(9)4-6(7)8/h2-4H,9H2,1H3

Upstream product

• 92847-23-9 N-(3-bromo-4-methoxy)phenylsuccinimide 
• 638159-26-9 N-(3-bromo-4-methoxyphenyl)benzamide 
• 99-59-2 3-amino-4-methoxynitrobenzene 
• 2314-80-9 2-(4-methoxyphenyl)succinimide 
• 104-94-9 4-methoxy-aniline 
• 578-57-4 2-bromoanisole 
• 72054-82-1 3-Bromo-4,4-dimethoxy-2,5-cyclohexadien-1-one 
• 17332-12-6 3-bromo-4-methoxy-phenol 
• 591-20-8 3-Bromophenol 
• 10025-69-1 tin(II) chloride dihdyrate 
• 5197-28-4 2-bromo-4-nitroanisole 
• 6943-73-3 N-(3-bromo-4-methoxyphenyl)acetamide 
• 7439-89-6 iron 
• 20265-97-8 p-anisidine hydrochloride 

Downstream Products

• 102236-13-5 3-bromo-4-methoxy-N,N-dimethyl-aniline 
• 103028-33-7 6-methoxy-7-bromoquinoline 
• 36023-01-5 5-bromo-6-methoxyquinoline 
• 728944-49-8 N-(3-bromo-4-methoxy-phenyl)-anthranilic acid 
• 25021-68-5 3,3'-Dibrom-4,4'-dimethoxy-thiocarbanilid 
• 23742-67-8 1-(3-Bromo-4-methoxy-phenyl)-3-(4-trifluoromethyl-phenyl)-urea 
• 1009318-86-8 1-(benzo[d][1,3]dioxol-5-yl)-N-(3-bromo-4-methoxyphenyl)cyclopropane-carboxamide 
• 38824-11-2 (2-aminophenyl)-(3-methoxyphenyl)methanone 
• 502767-44-4 N-(3-bromo-4-methoxy-phenyl)-N'-cycloheptyl-N-methyl-N-(1-methyl-piperidin-4-yl)-[1,3,5]triazine-2,4,6-triamine 
• 6943-73-3 N-(3-bromo-4-methoxyphenyl)acetamide 
• 1034293-10-1 4-azido-2-bromo-1-methoxybenzene 

Relevant academic research and scientific papers

The Kinetics of the Reactions of Picryl Chloride with Some Substituted Anilines. Part 6. 4-Substituted and 3,4-Disubstituted Anilines

Arrhenius parameters have been measured for the reactions of picryl chloride with the following substituted anilines in acetonitrile: 4-X- (X = F, Cl, Br, I, Me, or OMe); 3,4-X2- (X = Cl, Br, Me, or OMe); 4-X-3-nitro- (X = F, Cl, or Me); 3-X-4-methoxy- (X = F, Cl, Br, or I); 3-fluoro-4-nitro-; and 3,4,5-trimethoxy-aniline.In the 3,4-disubstituted series the effect of two methyl groups on the free energy of activation is strictly additive, but for the rest the measured rate constants are greater than those calculated on the assumption of additivity.The results are rationalized in terms of the positions of the transition state on the reaction co-ordinate.

C-H Amination of Arenes with Hydroxylamine

This Letter describes the development of a TiIII-mediated reaction for the C-H amination of arenes with hydroxylamine. This reaction is applied to a variety of electron-rich (hetero)arene substrates, including a series of natural products and pharmaceuticals. It offers the advantages of mild conditions (room temperature), fast reaction rates (30 min), compatibility with ambient moisture and air, scalability, and the use of inexpensive commercial reagents.

SUBSTITUTED ISOXAZOLOPYRIDAZINONES AND ISOTHIAZOLOPYRIDAZINONES AND METHODS OF USE

Compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by positive allosteric modulation of the γ-aminobutyric acid B (GABA-B) receptor. Methods for making the compounds are described. Also described are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.

Fe-Catalyzed Amination of (Hetero)Arenes with a Redox-Active Aminating Reagent under Mild Conditions

A novel and efficient Fe-catalyzed direct C?H amination (NH2) of arenes is reported using a new redox-active aminating reagent. The reaction is simple, and can be performed under air, mild, and redox-neutral conditions. This protocol has a broad substrate scope and could be used in the late-stage modification of bioactive compounds. Mechanistic studies demonstrate that a radical pathway could be involved in this transformation.

Direct synthesis of anilines and nitrosobenzenes from phenols

A one-pot synthesis of anilines and nitrosobenzenes from phenols has been developed using an ipso-oxidative aromatic substitution (iSOAr) process. The products are obtained in good yields under mild and metal-free conditions. The leaving group effect on reactions that proceed through mixed quionone monoketals has also been investigated and a predictive model has been established.

Nitrogen-doped graphene-activated iron-oxide-based nanocatalysts for selective transfer hydrogenation of nitroarenes

Nanoscaled iron oxides on carbon were modified with nitrogen-doped graphene (NGr) and found to be excellent catalysts for the chemoselective transfer hydrogenation of nitroarenes to anilines. Under standard reaction conditions, a variety of functionalized and structurally diverse anilines, which serve as key building blocks and central intermediates for fine and bulk chemicals, were synthesized in good to excellent yields.

Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

5-HT RECEPTOR MODULATORS

The invention relates to compounds of formula (I), useful for treating disorders mediated by the 5-hydroxytryptamine (serotonin) receptor IB (5-HT1B), e.g. vascular disorders, cancer and CNS disorders. The invention also provides methods of treating such disorders, and compounds and compositions etc. for their treatment.

5-HT RECEPTOR MODULATORS

The invention relates to compounds of formula (I), useful for treating disorders mediated by the 5-hydroxytryptamine (serotonin) receptor 1B (5-HT1B), e.g. vascular disorders, cancer and CNS disorders. The invention also provides methods of treating such disorders, and componnds and compositions etc. for their treatment

Synthesis and antitrypanosomal evaluation of derivatives of N-benzyl-1,2-dihydroquinolin-6-ols: Effect of core substitutions and salt formation

Analogs of the trypanocidal lead compound 1-benzyl-1,2-dihydro-2,2,4- trimethylquinolin-6-yl acetate were prepared to extend the structure-activity relationship in this series of molecules, improve the in vivo antitrypanosomal activity of the lead, and de