73594-87-3

Upstream product

• 67-56-1 methanol 
• 17849-23-9 α-chloro-β-(4-methoxyphenyl)propionitrile 
• 292638-85-8 acrylic acid methyl ester 
• 104-94-9 4-methoxy-aniline 

Downstream Products

• 184840-77-5 5-[(4-methoxyphenyl)-methyl]thiazolidine-2,4-dione 
• 74772-78-4 5-(4-hydroxybenzyl)-2,4-thiazolidinedione 
• 61780-18-5 methyl 2-amino-3-(4-methoxyphenyl) propanoate 
• 124902-50-7 3-(4-Methoxy-phenyl)-2-thiocyanato-propionic acid methyl ester 

Relevant academic research and scientific papers

Chloride based ionic liquids as promoting agents for Meerwein reaction in solventless conditions

Chloride based ionic liquids were used as chloride source in Meerwein reaction either in [bmim]X (bmim = 1-butyl-3-methylimidazolium, X = BF4, PF6) as solvents or in solventless conditions. Satisfactory yields (49-71%) with diversely

Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis

The subject invention provides pharmaceutical compounds useful in the treatment of Type II diabetes. These compounds are advantageous because they are readily metabolized by the metabolic drug detoxification systems. Particularly, thiazolidinedione analogs that have been designed to include esters within the structure of the compounds are provided. This invention is also drawn to methods of treating disorders, such as diabetes, comprising the administration of therapeutically effective compositions comprising compounds that have been designed to be metabolized by serum or intracellular hydrolases and esterases. Pharmaceutical compositions of the ester-containing thiazolidinedione analogs are also taught.

Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis

The subject invention provides pharmaceutical compounds useful in the treatment of Type II diabetes. These compounds are advantageous because they are readily metabolized by the metabolic drug detoxification systems. Particularly, thiazolidinedione analogs that have been designed to include esters within the structure of the compounds are provided. This invention is also drawn to methods of treating disorders, such as diabetes, comprising the administration of therapeutically effective compositions comprising compounds that have been designed to be metabolized by serum or intracellular hydrolases and esterases. Pharmaceutical compositions of the ester-containing thiazolidinedione analogs are also taught.

MATERIALS AND METHODS FOR THE TREATMENT OF DIABETES, HYPERLIPIDEMIA, HYPERCHOLESTEROLEMIA, AND ATHEROSCLEROSIS

The subject invention provides pharmaceutical compounds useful in the treatment of Type II diabetes. These compounds are advantageous because they are readily metabolized by the metabolic drug detoxification systems. Particularly, thiazolidinedione analogs that have been designed to include esters within the structure of the compounds are provided. This invention is also drawn to methods of treating disorders, such as diabetes, comprising the administration of therapeutically effective compositions comprising compounds that have been designed to be metabolized by serum or intracellular hydrolases and esterases. Pharmaceutical compositions of the ester-containing thiazolidinedione analogs are also taught.

Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis

The subject invention provides pharmaceutical compounds useful in the treatment of Type II diabetes. These compounds are advantageous because they are readily metabolized by the metabolic drug detoxification systems. Particularly, thiazolidinedione analogs that have been designed to include esters within the structure of the compounds are provided. This invention is also drawn to methods of treating disorders, such as diabetes, comprising the administration of therapeutically effective compositions comprising compounds that have been designed to be metabolized by serum or intracellular hydrolases and esterases. Pharmaceutical compositions of the ester-containing thiazolidinedione analogs are also taught.

Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis

The subject invention provides pharmaceutical compounds useful in the treatment of Type II diabetes. These compounds are advantageous because they are readily metabolized by the metabolic drug detoxification systems. Particularly, thiazolidinedione analogs that have been designed to include esters within the structure of the compounds are provided. This invention is also drawn to methods of treating disorders, such as diabetes, comprising the administration of therapeutically effective compositions comprising compounds that have been designed to be metabolized by serum or intracellular hydrolases and esterases. Pharmaceutical compositions of the ester-containing thiazolidinedione analogs are also taught.

Arenediazonium tetrachlorocuprates(II). Modified versions of the Meerwein and Sandmeyer reactions

Chloroarylation of unsaturated compounds with arenediazonium chlorides in the presence of CuCl2 as catalyst involves intermediate formation of arenediazonium tetrachlorocuprates(II) [ArN2+] 2 CuCl4su

Arenediazonium tetrachlorocuprates(ii). Modification of the meerwein and sandmeyer reactions

In the copper-catalysed reactions of arenediazonium chlorides with unsaturated compounds arenediazonium tetrachlorocuprates(II) are formed as intermediates. A general method of preparation of these complexed diazonium salts is described. In polar solvents these salts undergo chlorinative dediazoniation to give chloroarenes in high yield. The reaction of an arenediazonium tetrachlorocuprate(II) with an activated alkene results in the same products as the Meerwein reaction. A radical cation mechanism for this reaction is proposed.

Titanium tetrachloride-mediated carbon-carbon chlorocyanoethylation of anisole: Synthesis of tyrosine derivatives

Chlorocyanoethylation of anisole with 2-chloroacrylonitrile in presence of titanium tetrachloride furnished α-chloro-β-(4-methoxyphenyl)propionitrile. This on simple reaction sequence was converted to (±) methyl-α-amino-β-(4-methoxyphenyl)propionate, a ty

Arylation of olefins

An olefin, especially an activated olefin, is arylated by reaction with an arylamine, such as an aniline, in an inert polar organic solvent and in the presence of an alkyl nitrite, a hydrogen halide, and a catalytic amount of a copper catalyst having the copper in an oxidation state below +2.