736-51-6Relevant academic research and scientific papers
Synthesis and investigation of antimicrobial activity of some nifuroxazide analogues
Alsaeedi, Huda S.,Aljaber, Nabila A.,Ara, Ismet
, p. 3639 - 3646 (2015/12/26)
A series of nifuroxazide analogues [(2a-2e)-(10a-10f)] have been synthesized, structurally identified and tested for antimicrobial activity against a panel of bacteria (Gram-positive and Gram-negative) and the yeast-like pathogenic fungus Candida albicans. The most active compound in this series was 4-amino-benzoic acid (5-nitro-furan-2-ylmethylene)-hydrazide (2b) and 2-amino-benzoic acid (5-nitrofuran-2-ylmethylene)-hydrazide (2d). Furthermore, compounds (9a-9g) and (10a-10g) recorded no activity against selected species except compounds (9f) and (10f) suggesting that using furoic hydrazide and the corresponding hydrazide of thiophene did not improve the antimicrobial activities for this type of compounds. Regarding the activity against Candida albicans, all compounds showed no activity with an exception of substituted nitro furan (2a-2d).
Exploring 5-nitrofuran derivatives against nosocomial pathogens: Synthesis, antimicrobial activity and chemometric analysis
Zorzi, Rodrigo Rocha,Jorge, Salomao Doria,Palace-Berl, Fanny,Pasqualoto, Kerly Fernanda Mesquita,Bortolozzo, Leandro De Sa,De Castro Siqueira, Andre Murillo,Tavares, Leoberto Costa
supporting information, p. 2844 - 2854 (2014/05/06)
The burden of nosocomial or health care-associated infection (HCAI) is increasing worldwide. According to the World Health Organization (WHO), it is several fold higher in low- and middle-income countries. Considering the multidrug-resistant infections, t
Synthesis and biological activity of nifuroxazide and analogs
Tavares,Penna,Amaral
, p. 244 - 249 (2007/10/03)
Nifuroxazide and thirteen analogs were synthesized from substituted benzoic acids and minimal inhibitory concentrations were determined using the serial dilution tests, in three sequential steps. Nifuroxazide and chloramphenicol were used as reference standards. The tests were performed in TSB against the standard bacterial strain of Staphylococcus aureus ATCC 25923.
