73608-71-6

Upstream product

• 421-20-5 Methyl fluorosulfonate 
• 81835-67-8 3,3-ethylenedioxy-4-methyl-N-(3,4,5-trimethoxybenzylidene)pentylamine 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 72189-37-8 4-methyl-1-methylamino-3-pentanone hydrochloride 
• 81835-61-2 4-methyl-1-phthalimido-3-pentanone 
• 81835-63-4 4-methyl-1-phthalimido-3-pentanone ethylene acetal 
• 73608-65-8 N(trimethoxy-3,4,5 benzylidene) methylamine 
• 73608-66-9 1,3,3-trimethyl-4-(3,4,5-trimethoxyphenyl)-2-azetidone 
• 74611-10-2 ethyl 3-(β-carbethoxyethylmethylamino)-3-(3,4,5-trimethoxyphenyl)-2,2-dimethylpropionate 
• 81835-65-6 1-amino-4-methyl-3-pentanone ethylene acetal 
• 32830-98-1 1-chloro-4-methyl-pentan-3-one 
• 81835-73-6 3,3-dimethyl-2-(3,4,5-trimethoxyphenyl)-4-piperidone 
• 74-88-4 methyl iodide 
• 74611-11-3 5-carbethoxy-1,3,3-trimethyl-2-(3,4,5-trimethoxyphenyl)-4-piperidone 

Downstream Products

• 58780-84-0 1,3,3-trimethyl-2-(3,4,5-trimethoxyphenyl)-4-methylenepiperidine 

Relevant academic research and scientific papers

Determination of Rotational Barriers of Carbon-Carbon Bonds in 2-Arylpiperidines

Carbon-carbon sp3-sp2 rotational barriers of 3,3-dimethyl-2-(3,4,5-trimethoxyphenyl)-4-piperidones and treir ethylene ketals have been evaluated using nmr techniques.The conformation of 1 hydrochloride has been studied by NOE determinations.Values found for the hydrochlorides of the title compounds are discussed in terms of equilibria with free bases and nitrogen inversion.

A Novel Synthesis of 2-Aryl-4-Piperidones By Mannich Cyclization of Iminoketals (1)

2-Aryl-4-piperidones have been synthesized by condensation between an aromatic aldehyde and a β-aminoketone ethylene ketal, and further cyclization of the resulting iminoketal with dry hydrogen chloride or anhydrous p-toluenesulfonic acid.Alternatively, r

MANNICH CYCLIZATION INVOLVING THE α-POSITION OF KETALS: SYNTHESIS OF 2-ARYL-4-PIPERIDONES AND 2-ARYL-3-ACYLPYRROLIDINES

A new method for the preparation of 2-aryl-4-piperidones and 2-aryl-3-acylpyrrolidines based on the acid-induced intramolecular cyclization between an iminium salt and the α-position of a ketal group is reported.

A Reinvestigation of the Stevens Rearrangement of 1-Benzyl-1,3,4-trimethyl-1,2,5,6-tetrahydropyridinium Salts

Authentic samples of 1,3,3-trimethyl-2-(3,4,5-trimethoxyphenyl)-4-methylenepiperidine (Ia) and 2-(p-chlorophenyl)-1,3,3-trimethyl-4-methylenepiperidine (Ib) are prepared by Mannich condensation between 4-methyl-1-methylamino-3-pentanone hydrochloride (VI)

A Reinvestigation of the Stevens Rearrangement of 1,3,4-Trimethyl-1-(3,4,5-trimethoxybenzyl)-1,2,5,6-tetrahydropyridinium Chloride

1,3,3-Trimethyl-2-(3,4,5-trimethoxyphenyl)-4-methylenepiperidine (XI) is prepared in an unambiguous way which involves the Reformatsky reaction followed by ethanolysis on the N-(3,4,5-trimethoxybenzylidene)methylamine, later treatment of the resulting ami