81835-61-2

Upstream product

• 32830-98-1 1-chloro-4-methyl-pentan-3-one 
• 1074-82-4 potassium phtalimide 

Downstream Products

• 81835-65-6 1-amino-4-methyl-3-pentanone ethylene acetal 
• 81835-76-9 1,3,3-trimethyl-2-(3,4,5-trimethoxyphenyl)-4-piperidone ethylene acetal 
• 81835-70-3 3,3-dimethyl-2-(3,4,5-trimethoxyphenyl)-4-piperidone ethylene acetal 
• 73608-71-6 1,3,3-trimethyl-2-(3,4,5-trimethoxyphenyl)-4-piperidone 
• 81835-73-6 3,3-dimethyl-2-(3,4,5-trimethoxyphenyl)-4-piperidone 
• 81835-67-8 3,3-ethylenedioxy-4-methyl-N-(3,4,5-trimethoxybenzylidene)pentylamine 

Relevant academic research and scientific papers

A Novel Synthesis of 2-Aryl-4-Piperidones By Mannich Cyclization of Iminoketals (1)

2-Aryl-4-piperidones have been synthesized by condensation between an aromatic aldehyde and a β-aminoketone ethylene ketal, and further cyclization of the resulting iminoketal with dry hydrogen chloride or anhydrous p-toluenesulfonic acid.Alternatively, r

MANNICH CYCLIZATION INVOLVING THE α-POSITION OF KETALS: SYNTHESIS OF 2-ARYL-4-PIPERIDONES AND 2-ARYL-3-ACYLPYRROLIDINES

A new method for the preparation of 2-aryl-4-piperidones and 2-aryl-3-acylpyrrolidines based on the acid-induced intramolecular cyclization between an iminium salt and the α-position of a ketal group is reported.