736080-30-1

Basic information

• Product Name: Benzoic acid, 4-[[(aminoiminomethyl)amino]methyl]-, methyl ester
• Synonyms: Methyl 4-(guanidinoMethyl)benzoate;Methyl 4-(carbamimidamidomethyl)benzoate;4-Guanidinomethylbenzoic acid methyl ester;4-[[(Aminoiminomethyl)amino]methyl]benzoic acid methyl ester;Benzoic acid, 4-[[(aminoiminomethyl)amino]methyl]-, methyl ester
• CAS NO: 736080-30-1
• Molecular Formula: C₁₀H₁₃N₃O₂
• Molecular Weight: 207.23
• Mol File: 736080-30-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzoic acid, 4-[[(aminoiminomethyl)amino]methyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[[(aminoiminomethyl)amino]methyl]-, methyl ester(736080-30-1)
• EPA Substance Registry System: Benzoic acid, 4-[[(aminoiminomethyl)amino]methyl]-, methyl ester(736080-30-1)

Safety Data

• Hazardous Substances Data: 736080-30-1(Hazardous Substances Data)

Upstream product

• 6232-11-7 methyl 4-(aminomethyl)benzoate hydrochloride 
• 4023-02-3 1H-pyrazole-1-carboximidamide hydrochloride 

Downstream Products

• 849235-68-3 4-(([4-(pyridin-3-yl)pyrimidin-2-yl]amino)methyl)benzoic acid 
• 726169-73-9 mocetinostat 
• 1448350-15-9 3-amino-4-[4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzamido]benzoic acid 
• 1448350-14-8 benzyl 3-amino-4-[4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzamido]benzoate 
• 1448350-20-6 benzyl 3-nitro-4-{[4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzene]amido}benzoate 
• 1448350-13-7 N-[2-amino-4-(hydroxymethyl)phenyl]-4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzamide 
• 1448350-12-6 N-(2-amino-4-{[(tert-butyldimethylsilyl)oxy]methyl}phenyl)-4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzamide 
• 1448350-19-3 N-(4-{[(tert-butyldimethylsilyl)oxy]methyl}-2-nitrophenyl)-4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzamide 
• 1448350-11-5 N-(2-amino-4-hydroxyphenyl)-4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzamide 
• 1448350-10-4 N-(2-amino-4-methoxyphenyl)-4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzamide 
• 1448350-09-1 N-(2-amino-4-bromophenyl)-4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzamide 
• 1448350-08-0 N-(2-amino-4-phenylphenyl)-4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzamide 
• 1448350-17-1 N-(2-nitro-4-phenylphenyl)-4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzamide 
• 1448350-07-9 N-(3-aminonaphthalen-2-yl)-4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzamide 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF SUBSTITUTED PYRIMIDINES

This invention relates to an improved process of making compounds of Formula (I) and synthetic intermediates thereof. (I) In particular, the invention relates to an improved process to prepare N-(2-aminophenyl)-4- ((pyrimidin-2-ylamino)methyl)benzamides which requires fewer steps, is efficient, can be used on an industrial scale, and results in a final product which is suitable for pharmaceutical use.

INHIBITORS OF HISTONE DEACETYLASE

The invention relates to a series of compounds useful for inhibiting histone deacetylase (HDAC) enzymatic activity. The invention also provides a method for inhibiting histone descetylase in a cell using said compounds as well as a method for treating cell proliferative diseases and conditions using said HDAC inhibitors. Further, the invention provides pharmaceutical compositions comprising the HDAC inhibiting compounds and a pharmaceutically acceptable carrier.

Synthesis of esters of guanidinobenzoic acids and guanidinomethylbenzoic acids with antiproteolytic activity

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