73611-42-4Relevant academic research and scientific papers
IBX-mediated oxidation of unactivated cyclic amines: application in highly diastereoselective oxidative Ugi-type and aza-Friedel-Crafts reactions
De Graaff,Bensch,Van Lint, Matthijs J.,Ruijter,Orru
supporting information, p. 10108 - 10112 (2015/10/20)
The first o-iodoxybenzoic acid (IBX) mediated oxidation of unactivated amines to imines is described. A range of meso-pyrrolidines were shown to be suitable substrates. The chemical space was further explored with one-pot oxidative Ugi-type and aza-Friedel-Crafts reactions, which proved to be highly diastereoselective.
Synthesis and characterization of novel bi- and tricyclic α-amino acids
Johnson, Matthew R.,Gauuan, Jolicia F.,Guo, Cheng,Guzzo, Peter R.,Le, Van-Duc,Shenoy, Rajesh A.,Hamby, James,Roark, Howard,Stier, Michael,Mangette, John E.
, p. 2769 - 2793 (2011/08/22)
As part of a medicinal chemistry collaboration, a number of novel bi- and tricyclic aamino acids were prepared through various routes and characterized by 1 H nuclearOverhauser effect difference experiments. The syntheses provide a number of routes to access some highly substituted amino acid derivatives that have not been reported previously. It is envisaged that the chemistry described here could be applied to the synthesis of other unique substrates Taylor & Francis Group, LLC.
