Cas 736176-90-2,1-(4-phenylthiazol-2-yl)-4-(thiophen-3-yl)-1H-imidazol-2-amine

736176-90-2

Post Buying Request

Basic information

Product Name: 1-(4-phenylthiazol-2-yl)-4-(thiophen-3-yl)-1H-imidazol-2-amine
Synonyms:
CAS NO:736176-90-2
Molecular Formula:
Molecular Weight: 324.43
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 1-(4-phenylthiazol-2-yl)-4-(thiophen-3-yl)-1H-imidazol-2-amine(CAS DataBase Reference)
NIST Chemistry Reference: 1-(4-phenylthiazol-2-yl)-4-(thiophen-3-yl)-1H-imidazol-2-amine(736176-90-2)
EPA Substance Registry System: 1-(4-phenylthiazol-2-yl)-4-(thiophen-3-yl)-1H-imidazol-2-amine(736176-90-2)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 736176-90-2(Hazardous Substances Data)

Suppliers
Usage
Upstream product
Downstream Products
Article

736176-90-2 Suppliers

Recommended suppliers

736176-90-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 736176-90-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,3,6,1,7 and 6 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 736176-90:
(8*7)+(7*3)+(6*6)+(5*1)+(4*7)+(3*6)+(2*9)+(1*0)=182
182 % 10 = 2
So 736176-90-2 is a valid CAS Registry Number.

736176-90-2Upstream product

736176-90-2Downstream Products

736176-90-2Relevant academic research and scientific papers

Synthesis and biological evaluation of 2-amino-1-thiazolyl imidazoles as orally active anticancer agents

Li, Wen-Tai,Hwang, Der-Ren,Song, Jen-Shin,Chen, Ching-Ping,Chen, Tung-Wei,Lin, Chi-Hung,Chuu, Jiunn-Jye,Lien, Tzu-Wen,Hsu, Tsu-An,Huang, Chen-Lung,Tseng, Huan-Yi,Lin, Chu-Chung,Lin, Heng-Liang,Chang, Chung-Ming,Chao, Yu-Sheng,Chen, Chiung-Tong

, p. 164 - 175 (2012/06/01)

Designed from a high throughput screened hit compound, novel 2-amino-1-thiazolyl imidazoles were synthesized and demonstrated cytotoxicity against human cancer cells. 1-(4-Phenylthiazol-2-yl)-4-(thiophen-2-yl)- 1Himidazol- 2-amine (compound 2), a 2-amino-1-thiazolyl imidazole, inhibited tubulin polymerization, interacted with the colchicine-binding sites of tubulins, and caused cell cycle arrest at the G2/M phase in human gastric cancer cells. Disruption of the microtubule structure in cancer cells by compound 2 was also observed. Compound 2 concentration-dependently inhibited the proliferation of cancer cells in histocultured human gastric and colorectal tumors. Given orally, compound 2 prolonged the lifespans of leukemia mice intraperitoneally inoculated with the murine P388 leukemic cells. We report 2-amino-1-thiazolyl imidazoles as a novel class of orally active microtubuledestabilizing anticancer agents. Springer Science+Business Media, LLC 2010.

Imidazolamino compounds

-

Page 15, (2008/06/13)

The invention relates to novel imidazolamino compounds. Also disclosed are methods of treating cancer by using one of these compounds and pharmaceutical compositions containing one of these compounds.

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 736176-90-2