2507-81-5

Upstream product

• 2114-02-5 amidinothiocarbamide 
• 70-11-1 α-bromoacetophenone 
• 98-86-2 acetophenone 

Downstream Products

• 92150-11-3 6-methyl-2-(4-phenyl-thiazol-2-ylamino)-3H-pyrimidin-4-one 
• 33706-50-2 (5-chloro-4,6-dimethyl-pyrimidin-2-yl)-(4-phenyl-thiazol-2-yl)-amine 
• 33633-59-9 4-phenyl-1-(4-phenylthiazol-2-yl)-1H-imidazol-2-amine 
• 88067-18-9 (4,6-dimethyl-pyrimidin-2-yl)-(4-phenyl-thiazol-2-yl)-amine 
• 33633-62-4 4-(4-methoxy-phenyl)-1-(4-phenyl-thiazol-2-yl)-1H-imidazol-2-ylamine 
• 33633-65-7 4,5-diphenyl-1-(4-phenylthiazol-2-yl)-1H-imidazol-2-amine 
• 736176-82-2 1-(4-phenylthiazol-2-yl)-4-(thiophen-2-yl)-1H-imidazol-2-amine 
• 736176-90-2 1-(4-phenylthiazol-2-yl)-4-(thiophen-3-yl)-1H-imidazol-2-amine 
• 736176-87-7 1-(4-phenylthiazol-2-yl)-4-(pyridin-2-yl)-1H-imidazol-2-amine 
• 1070143-75-7 1-(4-phenylthiazol-2-yl)-4-(thiazol-2-yl)-1H-imidazol-2-amine 
• 736176-94-6 4-(furan-2-yl)-1-(4-phenylthiazol-2-yl)-1H-imidazol-2-amine 
• 33706-72-8 4,4'-diphenyl-2,2'-(4,4'-diphenyl-2,2'-diazenediyl-di-imidazol-1-yl)-bis-thiazole 
• 33706-58-0 2-{[4,5-diphenyl-1-(4-phenyl-thiazol-2-yl)-1H-imidazol-2-ylimino]-methyl}-phenol 

Relevant academic research and scientific papers

Arylbiamidines: Synthesis and structural studies en route to anticancer applications

Biamidines are a unique and poorly studied class of nitrogenous compounds prone to tautomerization and H-bonding. Four series of heteroaryl diarylbiamidines were synthesized and the antimelanoma activity and physicochemical properties of the resulting 37 new compounds were evaluated. The dimethylthiazolyl 3-bromophenyl biamidine derivative B6 inhibits the growth of six different melanoma cell lines, having higher activity than the positive control drug, the B-RAF inhibitor PLX4032. This study introduces diarylbiamidines as promising frameworks for drug discovery.

Method for synthesizing 2-guanidinothiazole compound by one-pot process

According to the invention, a substituted methyl ketone compound is innovatively used as a raw material, amidinothiourea is added into an alcohol solvent under the conditions of halogeno salt MX and Oxone, and a one-pot process one-step reaction is carried out to obtain the target 2-guanidinothiazole compound. Common methyl ketone is used for replacing an alpha-halogenated carbonyl compound whichis high in price and toxicity, MX which is low in price and easy to obtain is used as a halogen source, the method is novel, raw materials and reagents are cheap, reaction conditions are mild, and operation is easy and convenient, therefore low-cost, convenient and rapid synthesis of the 2-guanidinothiazole compound is achieved.