73644-87-8

Basic information

• Product Name: Pentanamide, N-(4-methoxyphenyl)-
• CAS NO: 73644-87-8
• Molecular Formula: C12H17NO2
• Molecular Weight: 207.272
• Mol File: 73644-87-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Pentanamide, N-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pentanamide, N-(4-methoxyphenyl)-(73644-87-8)
• EPA Substance Registry System: Pentanamide, N-(4-methoxyphenyl)-(73644-87-8)

Safety Data

• Hazardous Substances Data: 73644-87-8(Hazardous Substances Data)

Upstream product

• 104-94-9 4-methoxy-aniline 
• 2082-59-9 pentanoic anhydride 
• 638-29-9 n-valeryl chloride 
• 100-17-4 para-methoxynitrobenzene 
• 109-52-4 valeric acid 
• 4509-90-4 5-bromovaleroyl chloride 
• 182887-95-2 5-Bromo-pentanoic acid (4-methoxy-phenyl)-amide 

Downstream Products

• 882-42-8 N-(4-methoxy-phenyl)-N-pentyl-amine 
• 35228-40-1 N-(4-methoxyphenyl)pentanethioamide 

Relevant articles and documents

Lewis Base-Boryl Radicals Enabled the Desulfurizative Reduction and Annulation of Thioamides

A new protocol for radical transformations of thioamides promoted by Lewis base-boryl radicals is reported. The desulfurizative reduction to access organic amines was enabled utilizing 4-dimethylaminopyridine-BH3 as the boryl radical precursor and PhSH as the polarity reversal catalyst. Alternatively, the chain process for unsaturated thioamides was switched to an annulation reaction using N-heterocyclic carbene-BH3 as the boryl radical precursor and sterically bulky Ph3CSH as the catalyst, allowing for the construction of N-heterocyclic and carbocyclic skeletons.

N-Acyl-N-(4-chlorophenyl)-4-nitrobenzenesulfonamides: Highly selective and efficient reagents for acylation of amines in water

A variety of N-acyl-N-(4-chlorophenyl)-4-nitrobenzenesulfonamides (1a-e) were synthesized in one pot from 4-chloroaniline under solvent-free conditions and have been developed as chemoselective N-acylation reagents. Selective protection of primary amines in the presence of secondary amines, acylation of aliphatic amines in the presence of aryl amines, and monofunctionalization of primary-secondary diamines as well as selective N-acylation of amino alcohols using these reagents are described. All of the acylation reactions were carried out in water as a green solvent. High stability and easy preparation of these acylating reagents are other advantages of this method.

Development of new linkers for the formation of aliphatic C-H bonds on polymeric supports

Two polymeric linkers, 8 and 11, were prepared in high yields. Attachment of an alkyl group to these linkers was facile, and their cleavage from the MeO-PEG polymer support was accomplished by desulfurization using Raney nickel to yield the new carbon-hydrogen bond product 6. The protocol reported herein allows efficient preparation of new polymeric linkers as well as their possible application to combinatorial libraries.