73654-01-0Relevant academic research and scientific papers
Synthesis, characterization and anti-inflammatory activity of 2-(4-chlorobenzyl)-5-(di(5- substituted-1h-indol-3-yl)methyl)-6-(4-substituted phenyl)imidazo[2,1-b][1,3,4]thiadiazoles
SIDDIQ, AYESHA,SHAMANTH, SADASHIVAMURTHY,SALMAN, MOHAMMED,DHARMAPPA,KEMPEGOWDA, MANTELINGU,JAYARAMA, SHANKAR
, p. 2577 - 2582 (2020)
In present study, the anti-inflammatory potential of a series of 2-(4-chlorobenzyl)-5-(di(5-substituted-1H-indol-3-yl)methyl)-6-(4-substituted phenyl)imidazo[2,1-b][1,3,4]thiadiazoles (5a-e) were evuluated after characterizing through 1H NMR, 13C NMR spec
Identification of a novel BCL2-specific inhibitor that binds predominantly to the BH1 domain
Iyer, Divyaanka,Vartak, Supriya V.,Srivastava, Mrinal,Hegde, Mahesh,Gopalakrishnan, Vidya,Raghavan, Sathees C.,Mishra, Archita,Surolia, Avadhesha,Goldsmith, Gunaseelan,Velusamy, Mahesh,Choudhary, Bibha,Kumar, Sujeet,Karki, Subhas S.,Glenn, Mark,Kalakonda, Nagesh
, p. 3408 - 3437 (2016/12/31)
The antiapoptotic protein BCL2 is overexpressed in several cancers and contributes to prolonged cell survival and chemoresistance, lending itself as an excellent target for cancer therapy. Here, we report the design, synthesis, and characterization of Dis
2-(4-Chlorobenzyl)-6-arylimidazo[2,1-b][1,3,4]thiadiazoles: Synthesis, cytotoxic activity and mechanism of action
Kumar, Sujeet,Hegde, Mahesh,Gopalakrishnan, Vidya,Renuka, Vinaya Kumar,Ramareddy, Sureshbabu A.,De Clercq, Erik,Schols, Dominique,Gudibabande Narasimhamurthy, Anil Kumar,Raghavan, Sathees C.,Karki, Subhas S.
, p. 687 - 697 (2014/08/18)
The cytotoxic activity of a new series of 2-(4′-chlorobenzyl)-5,6- disubstituted imidazo[2,1-b][1,3,4]thiadiazoles against different human and murine cancer cell lines is reported. Among the tested compounds, two derivatives namely 2-(4-chlorobenzyl)-6-(2
