73654-59-8Relevant academic research and scientific papers
Automated synthesis of arabinoxylan-oligosaccharides enables characterization of antibodies that recognize plant cell wall glycans
Schmidt, Deborah,Schuhmacher, Frank,Geissner, Andreas,Seeberger, Peter H.,Pfrengle, Fabian
supporting information, p. 5709 - 5713 (2015/03/31)
Monoclonal antibodies that recognize plant cell wall glycans are used for high-resolution imaging, providing important information about the structure and function of cell wall polysaccharides. To characterize the binding epitopes of these powerful molecular probes a library of eleven plant arabinoxylan oligosaccharides was produced by automated solid-phase synthesis. Modular assembly of oligoarabinoxylans from few building blocks was enabled by adding (2-naphthyl)methyl (Nap) to the toolbox of orthogonal protecting groups for solid-phase synthesis. Conjugation-ready oligosaccharides were obtained and the binding specificities of xylan-directed antibodies were determined on microarrays. Automated synthesis meets plant research: Automated synthesis of plant oligosaccharides provides molecular tools for the characterization of important biological probes in plant research. The binding specificities of a collection of xylan-directed monoclonal antibodies have been determined by means of carbohydrate microarrays equipped with synthetic arabinoxylan fragments (see figure).
Phosphatidyl myo-inositol mannosides mimics built on an acyclic or heterocyclic core: Synthesis and anti-inflammatory properties
Front, Sophie,Court, Nathalie,Bourigault, Marie-Laure,Rose, Stephanie,Ryffel, Bernhard,Erard, Francois,Quesniaux, Valerie F.J.,Martin, Olivier R.
scheme or table, p. 2081 - 2093 (2012/07/01)
Phosphatidyl myo-inositol mannosides (PIMs) are constituents of the mycobacterial cell wall and possess immunomodulatory activities. Certain PIM derivatives have immunoprotective activity and are of interest as anti-inflammatory agents. In order to identi
STUDIES DIRECTED TOWARD THE TOTAL SYNTHESIS OF POLYCAVERNOSIDE A. ENANTIOSELECTIVE SYNTHESIS OF THE DISACCHARIDE COMPONENT
Johnston, Jeffrey N.,Paquette, Leo A.
, p. 4341 - 4344 (2007/10/02)
Adaptation of the Mukaiyama-Nicolaou protocol to the coupling of a monounprotected thioglycoside to a glycosyl fluoride is capable of delivering the unusual disaccharide present in the title toxin.
