73664-43-4

Usage

Uses

Used in Biochemical Research:
N,N-Dimethyl-2-iodoacetamide is used as a reagent for the selective modification of proteins and peptides, particularly through its ability to form stable thioether bonds with thiol groups. This selective modification capability is crucial for studying protein structure and function, as well as for the development of new bioconjugation methods.
Used in Organic Synthesis:
In the field of organic synthesis, N,N-Dimethyl-2-iodoacetamide serves as a key intermediate compound. Its reactive iodo group allows for various chemical transformations, making it a versatile building block for the synthesis of more complex organic molecules.
Used in Development of Bioconjugation Methods:
N,N-Dimethyl-2-iodoacetamide is utilized as a component in the development of innovative bioconjugation techniques. Its reactivity with thiols provides a means to covalently link biological molecules, which is essential for creating stable and functional bioconjugates for various applications in research and medicine.
Used in Labeling of Biological Molecules:
Due to its reactivity, N,N-Dimethyl-2-iodoacetamide is also used for the labeling of biological molecules. This allows researchers to track and visualize the behavior of these molecules within biological systems, providing insights into their roles and interactions.

InChI:InChI=1/C4H8INO/c1-6(2)4(7)3-5/h3H2,1-2H3

Upstream product

• 2675-89-0 2-chloro-N,N-dimethylacetamide 

Downstream Products

• 57084-18-1 gamma-dodecalactone 
• 554420-51-8 N-[7-(dimethylcarbamoylmethyl-methyl-amino)-4-methoxy-benzothiazol-2-yl]-4-fluoro-benzamide 
• 554420-55-2 N-[7-(dimethylcarbamoylmethyl-ethyl-amino)-4-methoxy-benzothiazol-2-yl]-4-fluoro-benzamide 
• 352306-79-7 4-Nitrobenzyl (1S,5R,6S)-2-[6-(N,N-dimethyl-carbamoylmethyl)-7-methylthioimidazo[5,1-b]thiazolium-2-yl]-6-((1R)-1-hydroxyethyl)-1-methyl-1-carbapen-2-em3-carboxylate iodide 

Relevant academic research and scientific papers

Coordination of 2,2-(Trifluoroazanediyl)bis(N, N-dimethylacetamide) with U(VI), Nd(III), and Np(V): A Thermodynamic and Structural Study

Thermodynamic properties of the complexation of 2,2-(trifluoroazanediyl)bis(N,N-dimethylacetamide) (CF3ABDMA) with U(VI), Nd(III), and Np(V) have been studied in 1.0 M NaNO3 at 25 °C. Equilibrium constants of the complexation were determined by potentiometry and spectrophotometry. In comparison with a series of structurally related amine-bridged diacetamide ligands, including 2,2-(benzylazanediyl)bis(N,N-dimethylacetamide) (BnABDMA), 2,2-azanediylbis(N,N-dimethylacetamide) (ABDMA), and 2,2-(methylazanediyl)bis(N,N-dimethylacetamide) (MABDMA), CF3ABDMA forms weaker complexes with U(VI), Nd(III), and Np(V) due to the lower basicity of the center N atom in CF3ABDMA resulting from the attachment of the strong electron-withdrawing CF3-moiety. The complexation strength of CF3ABDMA with the three metal ions follows the order: UO22+ > Nd3+ > NpO2+, consistent with the order of the effective charges of the metal ions. Structural information on the U(VI)/CF3ABDMA complexes in solution and in solid was obtained by theoretical computation, single crystal X-ray diffractometry, 19F NMR, and electrospray ionization mass spectrometry. The structural data indicate that, similar to the three previously studied amine-bridged diacetamide ligands (BnABDMA, ABDMA, and MABDMA), the CF3ABDMA ligand coordinates to UO22+ in a tridentate mode, through the center nitrogen and the two amide oxygen atoms.

NOVEL ANTIVIRAL PYRROLOPYRIDINE DERIVATIVES AND METHOD FOR PREPARING THE SAME

The present invention relates to a pyrrolopyridine derivative represented by the Chemical Formula I, and a racemate or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and relates to an antiviral composition including the same as an active ingredient. The compound of the Chemical Formula I has excellent antiviral activity and selectivity for wild type and resistant HIV-1, and thereby is useful as a therapeutic agent for acquired immune deficiency syndrome (AIDS).

NOVEL ANTIVIRAL PYRROLOPYRIDINE DERIVATIVE AND A PRODUCTION METHOD FOR SAME

The present invention relates to a pyrrolopyridine derivative represented by the Chemical Formula I, and a racemate or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and relates to an antiviral composition including the same as an active ingredient. The compound of the Chemical Formula I has excellent antiviral activity and selectivity for wild type and resistant HIV-1, and thereby is useful as a therapeutic agent for acquired immune deficiency syndrome (AIDS).