73676-99-0Relevant academic research and scientific papers
Catalytic asymmetric total synthesis of (S)-(-)-zearalenone, a novel lipoxygenase inhibitor
Baggelaar, Marc P.,Huang, Yange,Feringa, Ben L.,Dekker, Frank J.,Minnaard, Adriaan J.
, p. 5271 - 5274 (2013/09/02)
A catalytic asymmetric synthesis of (S)-(-)-zearalenone is reported using asymmetric allylic alkylation for the introduction of the stereocenter. (S)-(-)-Zearalenone turned out to be a novel lipoxygenase inhibitor.
Combination of RCM and the Pauson-Khand reaction: One-step synthesis of tricyclic structures
Rosillo, Marta,Arnaiz, Eduardo,Abdi, Delbrin,Blanco-Urgoiti, Jaime,Dominguez, Gema,Perez-Castells, Javier
experimental part, p. 3917 - 3927 (2009/04/07)
The combination of ring-closing metathesis (RCM) followed by an intramolecular Pauson-Khand reaction gives direct entry to tricyclic compounds. The RCM was carried out on a hexacarbonylcobalt-complexed alkyne, this complex acting as a protecting group against enyne metathesis. The procedure was studied for dienynes containing heteroatoms and allows the building of [6,5,5] and [7,5,5] tricyclic systems. The feasibility of the process depends strongly on the nature of the substrate. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
