73679-98-8

Upstream product

• 23402-75-7 lithium di-tertbutyl cuprate 
• 99-03-6 1-(3-aminophenyl)ethanone 
• 50777-64-5 2-(2-bromophenyl)-2-methyl-1,3-dioxolane 
• 156335-55-6 N-(1,1-dimethylethyl)-3-(2-methyl-1,3-dioxolan-2-yl)benzenamine 

Relevant academic research and scientific papers

Synthesis of 3-(N-Alkylamino)acetophenones via a Benzyne Intermediate

Reaction of 2-(2-bromophenyl)-2-methyl-1,3-dioxolane with lithium (1,1-dimethylethyl)amide, lithium (2,2-dimethylpropyl)amide, lithium (1,1-dimethylpropyl)amide gave the corresponding N-(alkyl)-3-(2-methyl-1,3-dioxolan-2-yl)benzenamines in moderate yields

Novel N-Alkylation of Amines with Organocopper Reagents

A mild and efficient method for the N-alkylation of amines is described, based on the oxidative coupling of lithium alkylcopper amide, which is derived from lithium dialkylcuprates and primary or secondary amines.The high chemospecificity of the method was demonstrated.