73680-15-6Relevant academic research and scientific papers
Last of the gem-Difluorocycloalkanes: Synthesis and Characterization of 2,2-Difluorocyclobutyl-Substituted Building Blocks
Chernykh, Anton V.,Melnykov, Kostiantyn P.,Tolmacheva, Nataliya A.,Kondratov, Ivan S.,Radchenko, Dmytro S.,Daniliuc, Constantin G.,Volochnyuk, Dmitriy M.,Ryabukhin, Sergey V.,Kuchkovska, Yuliya O.,Grygorenko, Oleksandr O.
, p. 8487 - 8496 (2019/08/30)
An efficient approach to synthesis of previously unavailable 2-substituted difluorocyclobutane building blocks was developed and applied on a multigram scale. The key step of the synthetic sequence included deoxofluorination of O-protected 2-(hydroxylmeth
Cyclopropanones. Formation of Vinylcyclopropanols and Their Rearrangement to Cyclobutanones
Wasserman, Harry H.,Hearn, Michael J.,Cochoy, Robert E.
, p. 2874 - 2880 (2007/10/02)
Vinylcyclopropanols, formed by the addition of vinylmagnesium bromide to the ethyl hemiketal of cyclopropanone, may be converted to cyclobutanone derivatives on reaction with various electrophiles.The ring enlargement of 1-vinyl-2-methylcyclopropanol takes place by preferential migration of the more highly substituted carbon atom.
