73691-11-9

Upstream product

• 3963-62-0 2,2-Diphenylethylamine 
• 123-76-2 levulinic acid 
• 591-12-8 5-methyl-2-furanone 
• 73691-10-8 4-Oxo-pentanoic acid (2,2-diphenyl-ethyl)-amide 
• 73691-09-5 ethyl 1,4-dioxopentyl carbonate 

Downstream Products

• 73691-12-0 1,5,6,10b-tetrahydro-10bα-methyl-6β-phenylpyrrolo<2,1-a>isoquinolin-3(2H)-one 
• 101249-00-7 (6S,10bS)-10b-Methyl-6-phenyl-1,2,3,5,6,10b-hexahydro-pyrrolo[2,1-a]isoquinoline; hydrochloride 

Relevant academic research and scientific papers

Hexahydropyrrolo[2,1-a]isoquinoline derivatives and antidepressant use thereof

Novel compounds are disclosed, which are derivatives of 1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]-isoquinolines, represented by general formula (I): STR1 as well as pharmaceutical compositions and methods for the treatment of depression in warm-blooded animals, e.g., man. Novel intermediates are also part of the invention.

Stereochemistry of Intramolecular Amidoalkylation Reactions in the Synthesis of Polycyclic Isoquinoline Derivatives

N-Acyliminium cyclizations onto benzenoid rings to give tetrahydroisoquinoline ring systems were studied.Particular attention was paid to the stereochemical effect of substituents present on the isoquinoline ring.High stereoselectivity (> 90 percent) was