73694-23-2

Upstream product

• 642-71-7 3,4,5-trimethoxyphenol 
• 853577-59-0 1-(6-hydroxy-2,3,4-trimethoxyphenyl)-2-methylpropan-1-one 

Downstream Products

• 853577-60-3 1-(2-hydroxy-3-isobutyl-4,5,6-trimethoxy-phenyl)-ethanone 
• 853577-72-7 3-(4-benzenesulfonyl-phenyl)-8-isobutyl-5,6,7-trimethoxy-2-methyl-chromen-4-one 
• 853577-69-2 8-isobutyl-5,6,7-trimethoxy-2-methyl-3-(4-phenoxy-phenyl)-chromen-4-one 
• 853577-71-6 3-biphenyl-4-yl-8-isobutyl-5,6,7-trimethoxy-2-methyl-chromen-4-one 
• 853577-70-5 4-(8-isobutyl-5,6,7-trimethoxy-2-methyl-4-oxo-4H-chromen-3-yl)-benzoic acid 
• 853577-68-1 8-isobutyl-5,6,7-trimethoxy-3-(4-methoxy-phenyl)-2-methyl-chromen-4-one 
• 853577-67-0 3-(4-chloro-phenyl)-8-isobutyl-5,6,7-trimethoxy-2-methyl-chromen-4-one 
• 853577-65-8 8-isobutyl-5,6,7-trimethoxy-2-methyl-3-phenyl-4H-chromen-4-one 

Relevant academic research and scientific papers

Structure-based design of flavonoid compounds as a new class of small-molecule inhibitors of the anti-apoptotic Bcl-2 proteins

Structure-based strategy was employed to design flavonoid compounds to mimic the Bim BH3 peptide as a new class of inhibitors of the anti-apoptotic Bcl-2 proteins. The most potent compound, 4 (BI-33), binds to Bcl-2 and Mcl-1 with Ki values of

CHROMEN-4-ONE INHIBITORS OF ANTI-APOPTOTIC BCL-2 FAMILY MEMBERS AND THE USES THEREOF

The invention relates to small molecules which function as inhibitors of anti-apoptotic Bcl-2 family member proteins (e.g., Bcl-2 and Bcl-xL). The invention also relates to the use of these compounds for inducing apoptotic cell death and sensitizing cells

Efficient synthesis of isoflavone analogues via a Suzuki coupling reaction

Analogues of 3-aryl-8-isobutyl-5,6,7-trihydroxy-2-methyl-4H-chromen-4-one were synthesized with high yields via the Suzuki coupling reaction of 3-iodo-8-isobutyl-5,6,7-trimethoxy-2-methyl-4H-chromen-4-one with different aryl boronic acids.