736989-93-8

Basic information

• Product Name: Methyl 6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-2-naphthoate
• Synonyms: Methyl 6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-2-naphthoate;6-(Methoxycarbonyl)naphthalene-2-boronic acid pinacol ester;methyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalene-2-carboxylate;(6-(METHOXYCARBONYL)NAPHTHALEN-2-YL)BORONIC ACID PINACOL ESTER
• CAS NO: 736989-93-8
• Molecular Formula: C₁₈H₂₁BO₄
• Molecular Weight: 312.16794
• Mol File: 736989-93-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 441.2±18.0 °C(Predicted)
• Appearance: /
• Density: 1.13±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Methyl 6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-2-naphthoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-2-naphthoate(736989-93-8)
• EPA Substance Registry System: Methyl 6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-2-naphthoate(736989-93-8)

Safety Data

• Hazardous Substances Data: 736989-93-8(Hazardous Substances Data)

Usage

General Description

Methyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-naphthoate, also known as CAS Number 253141-59-2, is a specialized chemical compound that is often used in a variety of complex chemical reactions, most notably in cross-coupling reactions. The presence of the tetramethyl-1,3,2-dioxaborolan-2-yl group allows the compound to undergo Suzuki-Miyaura cross-coupling, a type of chemical reaction where carbon-carbon bonds are formed from a halide and a boronic acid. Its structure also includes the naphthoate group, specifically 2-naphthoate, which can contribute to its aromatic compound characteristics. Overall, this compound is essential in high-level chemistry research and development, particularly in the field of synthetic organic chemistry.

Upstream product

• 5773-80-8 6-bromo-2-naphthoic acid 
• 33626-98-1 methyl 6-bromo-2-naphthoate 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 881408-70-4 methyl 6-[4-[2-[(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxy-ethyl]amino]ethyl]phenyl]-2-naphthoate 

Relevant articles and documents

Structure-Activity Relationship and Anticancer Profile of Second-Generation Anti-MRSA Synthetic Retinoids

We previously reported the antibacterial activity of CD437, a known antitumor compound. It proved to be a potent antimicrobial agent effective against both growing and persister cells of methicillin-resistant Staphylococcus aureus (MRSA). Herein, we report the synthesis of a panel of analogs and their effect on both MRSA and cancer cells. The hydrophobic group of the parent compound was varied in steric bulk, and lipid-mimicking analogs were tested. Biological assessment confirmed that the adamantane moiety is the most effective substitution for antibacterial activity, and some preferential action in cancer over MRSA was achieved.

N - heterocyclic compound, intermediate, preparation method, pharmaceutical composition and application (by machine translation)

The invention discloses a N - heterocyclic compound, intermediate, preparation method, pharmaceutical composition and application. The invention of SHP2 N - heterocyclic compound to have high selectivity, can effectively inhibit the cell in the SHP2 downstream signal path ERK phosphorylation level, to tumor cells has very good inhibition activity, it has broad drug development prospects; its preparation method is simple, mild reaction conditions, high yield and purity, after treatment is simple, environmental protection, and is favorable for industrial production. (by machine translation)

BIARYL DERIVATIVE AS GPR120 AGONIST

The present invention relates to a biaryl derivative expressed by the chemical formula 1, a method for producing the biaryl derivative, a pharmaceutical composition comprising same, and use of same, the biaryl derivative expressed by the chemical formula 1, as a GPR120 agonist, promoting GLP-1 generation in the gastro-intestinal tract, reducing insulin resistance in the liver, muscles and the like from anti-inflammatory activity in the macrophage, pancreatic cells and the like, and allowing effective use in prevention or treatment of inflammation or metabolic diseases such as diabetes, complications from diabetes, obesity, non-alcoholic fatty liver disease, fatty liver disease, and osteoporosis.