737005-18-4Relevant academic research and scientific papers
Adamantyl-substituted amino alcohols. Synthesis and functionalization at the nitrogen and oxygen nucleophilic centers
Kas'yan,Golodaeva,Kas'yan
, p. 1248 - 1255 (2003)
1-Aminoadamantanes and 1-aminomethyladamantanes were brought into reactions with p-nitrophenyloxirane and 9-carbazolylmethyloxirane. The reactions occurred in a regioselective fashion according to the Krasusky rule, which was confirmed by the 1H and 13C NMR data. The resulting amino alcohols having a p-nitrophenyl moiety were subjected to functionalization at the nitrogen and oxygen nucleophilic centers using p-nitrobenzenesulfonyl chloride, p-nitrobenzoyl chloride, and hexamethyldisilazane, and N,O-bisacyl derivative was synthesized. The structure of the products was proved by IR and 1H NMR spectroscopy.
