737007-16-8Relevant academic research and scientific papers
Experiences during synthesis of a dinucleating spacer incorporating 2-chloropyridine units through s and mayer reaction
Shukla, Satyendra N.,Gaur, Pratiksha,Mehrotra, Ripul,Srivastava, Radhey S.
, p. 593 - 597 (2012)
A bimetallic cuprous complex was accidentally reported, during synthesis of a dinucleating spacer incorporating two 2-chloropyridine units through S and mayer reaction. The product was characterized by elemental analysis, FAB-Mass, FT-IR, UV, magnetic susceptibility and 1H-NMR spectroscopic method. A possible mechanism is also proposed.
Synthesis, characterization, Catalytic and antibacterial activity of two series of dinuclear ruthenium sulphoxide complexes using 5,5'- methylenebis(pyridine) as bis-chelating bridging ligand
Shukla, Satyendra N.,Gaur, Pratiksha,Prasad, Mamta,Prasad, Mahender,Mehrotra, Ripul,Mathews, Sheela
, p. 485 - 493 (2012)
The reaction of a new heterocyclic bidentate N containing spacer, (ligand) 5,5'-methylenebis(pyridine) with ruthenium sulphoxide precursors resulted, dinuclear complexes. We herein report three formulations; [{cis,fac-RuCl 2(so)3}2(μ-mbp)].3so; [{trans,mer-RuCl 2(so)3}2(μ-mbp)].3so and [{trans-RuCl 4(so)}2(μ-mbp)]2-[X]2 +; where so = dimethyl-sulfoxide/tetramethylenesulfoxide; mbp = 5,5'-methylenebis(pyridine) and [X]+ = [(dmso)2H] +, Na+ or [(tmso)H]+. These complexes were characterized on the basis of elemental analyses, molar conductance measurement, magnetic susceptibility, FT-IR, 1H-NMR, 13C{1H}-NMR, electronic spectroscopy and FAB-Mass spectrometry. Catalytic activity of these complexes has been investigated in hydrolysis of benzonitrile. All the complexes exhibit good antibacterial activity against gram-negative bacteria Escherichia coli in comparison to Chloramphenicol.
Di-aryl guanidinium derivatives: Towards improved α2-Adrenergic affinity and antagonist activity
McMullan, Michela,Kelly, Brendan,Mihigo, Helene B.,Keogh, Aaron P.,Rodriguez, Fernando,Brocos-Mosquera, Iria,García-Bea, Aintzane,Miranda-Azpiazu, Patricia,Callado, Luis F.,Rozas, Isabel
supporting information, (2020/11/05)
Compounds with excellent receptor engagement displaying α2-AR antagonist activity are useful not only for therapeutic purposes (e.g. antidepressants), but also to help in the crystallization of this particular GPCR. Therefore, based on our broad experience in the topic, we have prepared eighteen di-aryl (phenyl and/or pyridin-2-yl) mono- or di-substituted guanidines and 2-aminoimidazolines. The in vitro α2-AR binding affinity experiments in human brain tissue showed the advantage of a 2-aminoimidazolinium cation, a di-arylmethylene core, a conformationally locked pyridin-2-yl-guanidine and a di-substituted guanidinium to achieve good α2-AR engagement. After different in vitro [35S]GTPγS binding experiments in human prefrontal cortex tissue, it was possible to identify that compounds 7a, 7b and 7c were α2-AR partial agonist, whereas 8h was a potent α2-AR antagonist. Docking and MD studies with a model of α2A-AR and two crystal structures suggest that antagonism is achieved by compounds carrying a di-substituted guanidine which substituent occupy a pocket adjacent to TM5 without engaging S2005.42 or S2045.46, and a mono-substituted cationic group, which favorably interacts with E942.65.
