73708-65-3

Basic information

• Product Name: Serinol hydrochloride
• Synonyms: 2-AMINO-1,3-PROPANEDIOL HYDROCHLORIDE;2-AMINO-1,3-PROPANDIOL HCL;DL-SERINOL HYDROCHLORIDE;SERINOL HCL;SERINOL HYDROCHLORIDE;SERINOL HYDROCHLORIDE (KG LEVEL);2-Amino-1,3-Propanediol Hydrochloride ( Serinol Hydrochloride;2-Amino-1,3-propanediol hydrochloride, 2-Amino-1,3-propanediol
• CAS NO: 73708-65-3
• Molecular Formula: C₃H₉NO₂*ClH
• Molecular Weight: 127.57
• Mol File: 73708-65-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 106-108 °C(lit.)
• Boiling Point: 266.7 °C at 760 mmHg
• Flash Point: 115.1 °C
• Appearance: white crystalline powder
• Vapor Pressure: 0.00116mmHg at 25°C
• Sensitive: Hygroscopic
• CAS DataBase Reference: Serinol hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Serinol hydrochloride(73708-65-3)
• EPA Substance Registry System: Serinol hydrochloride(73708-65-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• F: 3-10
• Hazardous Substances Data: 73708-65-3(Hazardous Substances Data)

Usage

Chemical Properties

white crystalline powder

InChI:InChI=1/C3H9NO2/c4-3(1-5)2-6/h3,5-6H,1-2,4H2/p+1

Upstream product

• 84820-75-7 4-Hydroxymethyl-2-trichlormethyl-4,5-dihydrooxazol 
• 534-03-2 serinol 
• 5680-80-8 methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride 

Downstream Products

• 902779-81-1 cis-[2-(3'-nitrophenyl)-1,3-dioxan-5-yl]amine 
• 13042-46-1 cis-(2-phenyl-[1,3]dioxan-5-yl)-amine 
• 902779-83-3 cis-[2-(4'-methylphenyl)-1,3-dioxan-5-yl]amine 
• 902779-82-2 cis-[2-(4'-chlorophenyl)-1,3-dioxan-5-yl]amine 
• 902779-80-0 cis-[2-(4'-nitrophenyl)-1,3-dioxan-5-yl]amine 
• 1258975-75-5 2-[2-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-3-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]-N-[2-hydroxy-1-(hydroxymethyl)ethyl]acetamide 

Relevant articles and documents

Epoxypropanol, a Building Block for Serinol Derivatives

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Toward the development of chemoprevention agents (III): Synthesis and anti-inflammatory activities of a new class of 5-glycylamino-2-substituted-phenyl-1,3-dioxacycloalkanes

A new series of 5-glycylamino-2-substituted-phenyl-1,3-dioxacycloalkanes were designed and synthesized. The anti-inflammatory activities of these compounds were tested using the xylene-induced mouse ear edema model. Sixteen of these new compounds exhibited comparable or better anti-inflammatory activities than aspirin suggesting that they can be further developed as potential anti-inflammatory drug leads. In addition, treatment with these anti-inflammatory agents did not prolong tail bleeding time in mice. The structure/activity relationships were also analyzed among these compounds. Considering their good efficacy and safety profiles, some 5-glycylamino-2-substituted-phenyl-1,3-dioxacycloalkanes are worthy to be explored further in assessing the possible link between anti-inflammation and cancer prevention.

Process for the purification of an aminoalcohol

The present invention relates to a process for the preparation of 2-amino-1,3-propanediol, having a content of organic impurities lower than 0.1% and inorganic impurities lower than 0.05%, comprising the following steps: a) formation of a 2-amino-1,3-propanediol salt with an acid; b) crystallization of the salt resulting from step a) from an aqueous or a hydro-organic mixture with a solvent selected from the group consisting of an alcohol of general formula R--OH, wherein R is a C1 -C6 straight or branched alkyl chain, and a mono(C1 -C3)alkylether of the (C3 -C7)alkylcellosolve group; c) elution of the free base by using ion exchangers to give an aqueous solution of said base; d) precipitation or crystallization of the solid 2-amino-1,3-propanediol from a solvent as defined in step b).