73708-65-3

Usage

Chemical Properties

white crystalline powder

InChI:InChI=1/C3H9NO2/c4-3(1-5)2-6/h3,5-6H,1-2,4H2/p+1

Upstream product

• 84820-75-7 4-Hydroxymethyl-2-trichlormethyl-4,5-dihydrooxazol 
• 534-03-2 serinol 
• 5680-80-8 methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride 

Downstream Products

• 902779-81-1 cis-[2-(3'-nitrophenyl)-1,3-dioxan-5-yl]amine 
• 13042-46-1 cis-(2-phenyl-[1,3]dioxan-5-yl)-amine 
• 902779-83-3 cis-[2-(4'-methylphenyl)-1,3-dioxan-5-yl]amine 
• 902779-82-2 cis-[2-(4'-chlorophenyl)-1,3-dioxan-5-yl]amine 
• 902779-80-0 cis-[2-(4'-nitrophenyl)-1,3-dioxan-5-yl]amine 
• 1258975-75-5 2-[2-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-3-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]-N-[2-hydroxy-1-(hydroxymethyl)ethyl]acetamide 

Relevant academic research and scientific papers

The hydrophilic ionic liquid at room temperature and its use (by machine translation)

PROBLEM TO BE SOLVED: To provide a novel ionic liquid that has a cation structure apt to become liquid, and is highly hydrophilic, particularly highly water-soluble, and use thereof.SOLUTION: This invention provides a hydrophilic room-temperature ionic liquid including a cation and an anion, the cation being a quaternary ammonium cation of the formula (I), where Rs independently represent a 2-8C straight-chain or branched-chain polyhydroxyalkyl group having two or more hydroxy groups, Rs independently represent a hydrogen atom or a 1-5C straight-chain or branched-chain monohydroxyalkyl group, and n represents an integer of 1-4.

Toward the development of chemoprevention agents (III): Synthesis and anti-inflammatory activities of a new class of 5-glycylamino-2-substituted-phenyl-1,3-dioxacycloalkanes

A new series of 5-glycylamino-2-substituted-phenyl-1,3-dioxacycloalkanes were designed and synthesized. The anti-inflammatory activities of these compounds were tested using the xylene-induced mouse ear edema model. Sixteen of these new compounds exhibited comparable or better anti-inflammatory activities than aspirin suggesting that they can be further developed as potential anti-inflammatory drug leads. In addition, treatment with these anti-inflammatory agents did not prolong tail bleeding time in mice. The structure/activity relationships were also analyzed among these compounds. Considering their good efficacy and safety profiles, some 5-glycylamino-2-substituted-phenyl-1,3-dioxacycloalkanes are worthy to be explored further in assessing the possible link between anti-inflammation and cancer prevention.

Toward the development of chemoprevention agents. Part II: Chemo-enzymatic synthesis and anti-inflammatory activities of a new class of 5-amino-2-substitutedphenyl-1,3-dioxacycloalkanes

A new series of optically pure 5-amino-2-substitutedphenyl-1,3-dioxacycloalkanes were designed and synthesized via a chemo-enzymatic combined method to develop new chemoprevention agents. Twenty-four of newly synthesized compounds significantly inhibited xylene-induced rat ear edema and exhibited comparable or better anti-inflammatory activities than the reference drug aspirin. Treatment of these anti-inflammatory agents did not prolong the tail bleeding time in rat. In addition, 5-amino-2-substitutedphenyl-1,3-dioxacycloalkanes exhibited good membrane permeability based on in vitro Caco-2 cell monolayer permeability assay. Furthermore, some preliminary structure-activity relationships were further analyzed among these compounds. Taken together, 5-amino-2-substitutedphenyl-1,3-dioxacycloalkanes may represent a new class of anti-inflammatory drugs with safer pharmacological profile.

Process for the purification of an aminoalcohol

The present invention relates to a process for the preparation of 2-amino-1,3-propanediol, having a content of organic impurities lower than 0.1% and inorganic impurities lower than 0.05%, comprising the following steps: a) formation of a 2-amino-1,3-propanediol salt with an acid; b) crystallization of the salt resulting from step a) from an aqueous or a hydro-organic mixture with a solvent selected from the group consisting of an alcohol of general formula R--OH, wherein R is a C1 -C6 straight or branched alkyl chain, and a mono(C1 -C3)alkylether of the (C3 -C7)alkylcellosolve group; c) elution of the free base by using ion exchangers to give an aqueous solution of said base; d) precipitation or crystallization of the solid 2-amino-1,3-propanediol from a solvent as defined in step b).

Process for production of 2-amino-1,3-propanediol

The present invention relates to a process of making 2-amino-1,3-propanediol by reacting 1,3-dihyrdroxyacetone dimer with an amine compound.

Proces for the preparation of 5-amino-2,2-dialkyl-1,3-dioxanes

A process for the preparation of 5-amino-2,2-dialkyl-1,3-dioxanes of formula wherein R and R1 have the meanings reported in the description, comprising the transformation of a 2,2-dialkyl-1,3-dioxan-5-carboxylic acid ester of formula wherein R2 has the meanings reported in the description into the corresponding amide and the subsequent rearrangement of this latter into the compounds of formula I, is described.