534-03-2 Usage
Chemical Properties
2-amino-1, 3-propanediol, which carries the trivial name of serinol, is an organic compound from the group of alkanolamines.The name serinol was chosen because of the structural similarity to the amino acidserine. In extension, derivatives thereof with substituents on the carbons of serinol are also called serinols.Under standard conditions, it is a solid, which is very soluble in water. 2-amino-1, 3-propanediol is a very stable, hygroscopic and corrosive substance.
Application
In biological field, the amino alcohol structure is widely found in many drugs especially antihistamines.
Serinol is used as an intermediate for non-ionic X-ray contrast agents like iopamidol (1-N,3-N-bi's (1,3-dihydroxypropan-2-yl) -5-[(2S) -2-hydroxypropanamido] -2,4,6-triiodobenzene-1,3-di-carboxamide, which is for example distributed as iopamiro?, isovue? (both Bracco Diagnostics Inc.) or scanlux? (Sanochemia). Iopamidol is employed as a contrast agent for angiography throughout the cardiovascular system.
Except the application in biochemical field, Serinol is used for the production of efficient anionic emulsifiers and nonionic polyethylene emulsions. It appears in personal care product formulations and show better base strength, lower neutral equivalent, and lower volatility than traditional amine emulsifiers.Furthermore, serinol constitutes a precursor for drugs dealing with pain treatment.
The difunctionality of serinol makes it useful as raw materials in polymer applications in both water- and solvent-based to increase the solubility of other components and improve solution stability. It functions as a pigment dispersion-aid dispersant to enhance the wetting and viscosity stability.
Serinol maintains a constant alkalinity in the boiling water flows and condensate not to form solid products which would impede line flow. It is applied for corrosion Inhibits. So it is widely employed in the preparation of water soluble cationic flocculants and ion exchange resins which adsorb solid and colloidal particles by electrostatic attraction. It is also used for water treatment, metal treatment and absorption of CO2 gas.
Uses
Different sources of media describe the Uses of 534-03-2 differently. You can refer to the following data:
1. 2-Amino-1,3-propanediol is used as an intermediate in several chemical applications and also useful for serinol and some of its derivatives.
2. Serinol may be used to prepare the artificial nucleic acids. It may be used in the synthesis of N-acylated serinol and C16-serinol affinity gel.
General Description
Serinol activates toxin production in the attenuated cultures of Helminthosporium sacchari. Preparation of polyesters derived from serinol is reported.
Check Digit Verification of cas no
The CAS Registry Mumber 534-03-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,3 and 4 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 534-03:
(5*5)+(4*3)+(3*4)+(2*0)+(1*3)=52
52 % 10 = 2
So 534-03-2 is a valid CAS Registry Number.
InChI:InChI=1/C3H9NO2/c4-3(1-5)2-6/h3,5-6H,1-2,4H2
534-03-2Relevant articles and documents
Novel method for producing 2-amino-1, 3-propylene glycol by JIT method
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Paragraph 0048-0051, (2021/11/26)
The invention belongs to the field of fine chemical engineering, and relates to a novel method for producing 2-amino-1, 3-propylene glycol by a JIT method, the novel method is composed of a catalytic chlorination reaction and a catalytic amination reaction, glycerol is chlorinated by hydrogen chloride under the catalysis of zinc chloride to obtain 2-chloro-1, 3-propylene glycol, and the 2-chloro-1, 3-propylene glycol is subjected to a catalytic reaction by urotropin to obtain 2-chloro-1, 3-propylene glycol.
2-amino-1, 3-propanediol synthesis process
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Paragraph 0007; 0017; 0018, (2019/04/06)
The invention discloses a 2-amino-1, 3-propanediol synthesis process. In a homogeneous system, nitromethane reacts with formalin in a methanol/water system by the aid of catalytic activity of organicalkali triethylamine catalysts to generate an intermediate product mainly comprising 2-nitro-1, 3-propanediol, the intermediate product is not separated in the homogeneous system, Raney nickel catalysts are directly added to perform catalytic hydrogenation reduction reaction and generate mixed mother solution taking 2-amino-1, 3-propanediol as a main product, and the mother solution is separated,concentrated, distilled, recrystallized, purified, separated and dried to obtain a finished product. Separation steps are simplified, the process is low in production equipment requirement, simple andconvenient in operation, less in wastewater discharge amount, low in cost and more suitable for industrial large-scale production and application, and the recycling rate of Raney nickels is effectively increased in the post-treatment process.
Serinol synthesis of new technology
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Page/Page column 4-7, (2018/04/01)
The invention relates to a serinol preparation method, and belongs to the technical field of serinol preparation through a reduction reaction, wherein serinol is an important intermediate of a non-ionic X-ray contrast agent iopamidol. According to the present invention, nitromethane and paraformaldehyde are adopted as raw materials, hydrogen is adopted as a reduction agent, and palladium/charcoal is adopted as a catalyst to prepare the serinol; and the method has characteristics of mature process, simple equipment and high serinol yield, and is suitable for industrial production.
