73709-20-3

Usage

Uses

Used in Pharmaceutical Research and Development:
N-(4-METHOXYPHENYL)GUANIDINEHYDROCHLORIDE is used as a therapeutic agent for treating various medical conditions, including hypertension and chronic pain, due to its potential to modulate biological processes and exhibit pharmacological properties beneficial in these areas.
Used in Laboratory Settings:
N-(4-METHOXYPHENYL)GUANIDINEHYDROCHLORIDE is used as a reagent in chemical synthesis and for its ability to modulate biological processes, making it a valuable tool in scientific research and experimentation.
Used in the Study of Guanidine-Based Drugs:
N-(4-METHOXYPHENYL)GUANIDINEHYDROCHLORIDE is used as a subject of interest in the study of guanidine-based drugs, contributing to the understanding and development of new pharmaceutical compounds with similar structures and therapeutic potential.

Upstream product

• 104-94-9 4-methoxy-aniline 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 158478-72-9 N,N′-di-tert-butoxycarbonyl-N″-(4-methoxy)phenylguanidine 
• 762264-83-5 N-benzyloxycarbonyl-N'-4-methoxyphenylguanidine 
• 158478-72-9 N,N′-bis(tert-butoxycarbonyl)-N′′-(4-methoxyphenyl)guanidine 
• 4023-02-3 1H-pyrazole-1-carboximidamide hydrochloride 

Downstream Products

• 112676-89-8 4-<<4-(3-pyridinyl)-2-pyrimidinyl>amino>phenol 
• 112676-90-1 4-[[4-(4-pyridinyl)-2-pyrimidinyl]amino]phenol 
• 112675-68-0 2-(4-methoxyphenyl)-4-(4-pyridinyl)-2-pyrimidine 
• 112675-67-9 N-(4-methoxyphenyl)-4-(pyridin-3-yl)pyrimidin-2-amine 

Relevant academic research and scientific papers

Ultrasound-assisted synthesis of substituted guanidines using 1H-pyrazole-1-carboxamidine and S-methylisothiouronium sulfate under solvent-free conditions

We have investigated ultrasound-assisted synthesis of guanidine derivatives using 1H-Pyrazole-1-carboxamidine (PyzCA) and S-substituted isothiouronium sulfate (MeITU). The guanylations of several amines are promoted by ultrasound sonication under solvent-free conditions, and proceed under mild conditions. It is of particular interest that the guanylations do not require bases in most cases.

Cleavage of 2-(Arylamino)-4,6-dimethoxypyrimidines to yield arylguanidines

A novel method for the synthesis of aryl-substituted guanidines in good overall yields is presented; it consists of the acidic cleavage of 2-(arylamino)-4,6-dimethoxypyrimidines, which were prepared by coupling aryl bromides with 2-amino-4,6-dimethoxypyrimidine. This methodology introduces a new means of protection for the guanidine functionality. Copyright

Upper rim guanidinocalix[4]arenes as artificial phosphodiesterases

Calix[4]arene derivatives, blocked in the cone conformation and functionalized with two to four guanidinium units at the upper rim were synthesized and investigated as catalysts in the cleavage of the RNA model compound 2-hydroxypropyl p-nitrophenyl phosp

Chlorotrimethylsilane activation of acylcyanamides for the synthesis of mono-N-acylguanidines

A simple and efficient one-pot method for the synthesis of monoprotected guanidines is presented. Treatment of an acylcyanamide with chlorotrimethylsilane generates a reactive N-silylcarbodiimide capable of guanylating a variety of amines. Typically the reaction is complete in 15 min for primary and secondary aliphatic amines at rt. Hindered amines and anilines are also competent nucleophiles but require extended reaction times.

Guanidine and 2-aminoimidazoline aromatic derivatives as α2-adrenoceptor antagonists, 1: Toward new antidepressants with heteroatomic linkers

The efficient preparation and pharmacological characterization of different families of (bis)guanidine and (bis)2-aminoimidazoline derivatives ("twin" and "half" molecules) as potential α2-adrenoceptor antagonists for the treatment of depressio

New cellulose-supported reagent: A sustainable approach to guanidines

(Chemical Equation Presented) A new cellulose-supported reagent for the synthesis of guanidine in aqueous medium is reported starting from commercially available functionalized cellulose beads. Primary and secondary amines, anilines, and amino acids were transformed to the corresponding guanidines in high yields and under very mild conditions.

Aminopyrimidine and aminopyridine anti-inflammation agents

Aminopyrimidine and aminopyridine (I) compounds, compositions and methods useful in the treatment of inflammatory, metabolic or malignant conditions, are provided herein.

Total deprotection of N,N'-bis(tert-butoxycarbonyl)guanidines using SnCl4

The total deprotection of NdV'-bis-Boc guanidines using SnCl4 proceeds smoothly in ethyl acetate at room temperature and leads to the easily isolable corresponding guanidinium chlorides.