73710-74-4

Basic information

• Product Name: methyl 2,3-dihydro-1H-pyrrolizine-7-carboxylate
• CAS NO: 73710-74-4
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.1891
• Mol File: 73710-74-4.mol

Chemical Properties

• Boiling Point: 288.4°C at 760 mmHg
• Flash Point: 128.2°C
• Density: 1.23g/cm³
• Vapor Pressure: 0.00234mmHg at 25°C
• Refractive Index: 1.585
• CAS DataBase Reference: methyl 2,3-dihydro-1H-pyrrolizine-7-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2,3-dihydro-1H-pyrrolizine-7-carboxylate(73710-74-4)
• EPA Substance Registry System: methyl 2,3-dihydro-1H-pyrrolizine-7-carboxylate(73710-74-4)

Safety Data

• Hazardous Substances Data: 73710-74-4(Hazardous Substances Data)

Upstream product

• 67985-73-3 1-formylpyrrolidine-2-carboxylic acid 
• 922-67-8 propynoic acid methyl ester 
• 1117-71-1 methyl-4-bromo-2-butenoate 
• 145474-57-3 N-(3-methoxycarbonylprop-2-enyl)pyrrolidine 

Relevant articles and documents

2,3-DIHYDRO-1H-PYRROLIZINE-7-FORMAMIDE DERIVATIVE AND APPLICATION THEREOF

The present application relates to a 2,3-dihydro-1H-pyrrolizine-7-formamide derivative as a nucleoprotein inhibitor and a use in preparation of a drug for treating HBV related diseases. The present application specifically relates to a compound represented by formula (II), and isomers or pharmaceutically acceptable salts thereof.

Total synthesis of Punicagranine

This communication details the first total synthesis of Punicagranine, a new pyrrolizine alkaloid isolated from the peels of the pomengranate, Punica granatum, the basis for traditional Chinese medicine, with anti-inflammatory activity. Two concise, 4–5 step routes were developed to rapidly prepare Punicagranine in 10.7–12.1% overall yields. One route features an intramolecular Heck reaction, while the other relies on a 1,3-dipolar cycloaddition. The latter route proceeds on scale to support future biological studies.

HEPATITIS B CAPSID ASSEMBLY MODULATORS

Described herein are hepatitis B capsid assembly modulators and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of hepatitis B.

X=Y-ZH Systems as Potential 1,3-Dipoles. Part 36. 1,5-Electrocyclisation Processes via Oxidation of Tertiary Amines. Pyrrolo-dihydroisoquinolines and -dihydro-β-carbolines.

A range of tertiary N-allylamines derived from 1,2,3,4-tetrahydroisoquinoline undergo oxidative cyclisation, induced by Ag2CO3, to pyrrolo-dihydroisoquinolines in moderate to good yield.Analogous oxidative cyclisations are reported for N-allyl-tetrahydro-