73713-67-4Relevant academic research and scientific papers
Synthesis of novel β-amino ketones containing a p-aminobenzoic acid moiety and evaluation of their antidiabetic activities
Tang, Guangxia,Yan, Jufang,Fan, Li,Xu, Jin,Song, Xiaoli,Jiang, Li,Luo, Lingfei,Yang, Dacheng
, p. 490 - 504 (2013/07/11)
The synthesis of two series of β-amino ketones containing a p-aminobenzoic acid moiety (TM-1 and TM-2) using a modified protocol of the Mannich reaction is reported. The molecular structures of a total of tweenty three new target compounds were characterized by 1H NMR, 13C NMR, ESI-MS and HR-MS. Subsequently, their antidiabetic activities were screened in vitro. The α-glucodase inhibition (α-GI) activity of compound 1e reached a remarkable level of 66.50%. The peroxisome proliferator-activated receptor (PPAR) relative activation activities of six compounds are above 80%, and in particular 2i displays an unprecedentedly high PPAR of 130.91%. The structure-activity relationships of the compounds were established. 2i is also subject to further in-depth investigation.
NOVEL 3,3-DIMETHYL TETRAHYDROQUINOLINE DERIVATIVES
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Page/Page column 66, (2011/11/01)
A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R5 have the significance given in claim 1, can be used as a medicament.
NOVEL 3,3-DIMETHYL TETRAHYDROQUINOLINE DERIVATIVES
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Page/Page column 26, (2011/10/31)
A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R5 have the significance given in claim 1, can be used as a medicament.
Investigation of the substituent specific cross-interaction effects on 13C NMR of the C=N bridging group in substituted benzylidene anilines
Cao, Chenzhong,Lu, Bingtao,Chen, Guanfan
experimental part, p. 335 - 341 (2011/10/09)
The substituent effect on 13C NMR of the C=N in benzylidene anilines XPhCH=NPhY was investigated, in which the substituents X and Y are in p-position or in m-position of the two aromatic rings. The substituent effects including the inductive effects of X and Y, the conjugative effects of X and Y, and the substituent specific cross-interaction effect were put into one model to quantify the 13C NMR chemical shift δC(C=N) of the C=N in XPhCH=NPhY. A penta-parameter correlation equation with correlation coefficient 0.9975 and standard error 0.17 ppm was obtained for 80 samples of compounds. The result shows that the substituents X and Y have an opposite effect on the δC(C=N). The electron-withdrawing effects of X decrease the δC(C=N); while the electron-donating effects of X increase the δC(C=N). In contrast, the electron-withdrawing effects of Y increase the δC(C=N); while the electron-donating effects of Y decrease the δC(C=N). A new substituent specific cross-interaction effect parameter δσ2 was proposed, which indicates that the most substituent specific cross-interaction effect exists in the pair of max electron-withdrawing group (EWG) and max electron-donating group (EDG) or the pair of max EDG and max EWG. Further to verify the obtained correlation equation, 15 samples of model compounds were prepared and their δC(C=N) was measured in this work. The predicted δC(C=N) values with the obtained equation are in good agreement with the measured ones for these prepared compounds, which confirmed the reliability of the obtained equation.
Synthesis of aminophosphonates with a primary amino group
Gavrilov
, p. 1708 - 1711 (2007/10/03)
Mono- and dinitro-substituted aromatic Shiff bases were reacted with diisopropyl hydrogen phosphite in the presence of the boron trifluoride-ether complex to obtain the corresponding α-aminophosphonates. Reduction of the nitro groups in the resulting phos
