73718-09-9

Usage

Uses

Used in Dye Manufacturing:
3-[4-(Dimethylamino)phenyl]propanoic acid is used as a chemical intermediate for the synthesis of dyes, taking advantage of its ability to form salts and engage in hydrogen bonding, which can influence the color and properties of the resulting dyes.
Used in Corrosion Inhibition:
3-[4-(Dimethylamino)phenyl]propanoic acid is used as a corrosion inhibitor, leveraging its interactions with metals to prevent or reduce corrosion. This application is particularly relevant in industries where metal protection is crucial, such as in the automotive, aerospace, and construction sectors.

InChI:InChI=1/C11H15NO2/c1-12(2)10-6-3-9(4-7-10)5-8-11(13)14/h3-4,6-7H,5,8H2,1-2H3,(H,13,14)/p-1

Upstream product

• 1552-97-2 3-[4-(dimethylamino)phenyl]-2-propenoic acid ethyl ester 
• 3984-22-3 2-vinyl-1,3-dioxolane 
• 586-77-6 4-bromo-N,N-dimethylaniline 
• 75567-86-1 3-(4-dimethylaminophenyl)propionic acid methyl ester 
• 15795-57-0 5-(4-N,N-dimethylaminobenzylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 139670-57-8 2-(4-dimethylaminophenyl)ethyl tosylate 
• 50438-75-0 2-(4-dimethylaminophenyl)ethyl alcohol 
• 1552-96-1 p-dimethylaminocinnamic acid 

Downstream Products

• 75567-86-1 3-(4-dimethylaminophenyl)propionic acid methyl ester 
• 139670-47-6 (1R,2R)-trans-cyclohexanediol mono-p-dimethylaminohydrocinnamate 
• 139670-46-5 (1R,2R)-trans-cyclohexanediol bis-p-dimethylaminohydrocinnamate 
• 1613696-27-7 4-(2-{5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[2-(morpholin-4-yl)ethyl]-1H-benzimidazol-2-yl}ethyl)-N,N-dimethylaniline 
• 52632-05-0 4-Dimethylaminophenethylamine 

Relevant academic research and scientific papers

Direct synthesis of 3-arylpropionic acids by tetraphosphine/palladium catalysed Heck reactions of aryl halides with acrolein ethylene acetal

Through the use of [PdCl(C3H5)]2/Cis,cis, cis-1,2,3,4-tetrakis(diphenylphosphinomethyl)cyclopentane as a catalyst, a range of aryl bromides undergoes Heck reaction with acrolein ethylene acetal. With this acetal, the selective formation of 3-arylpropionic acids/esters was observed. The functional group tolerance on the aryl halide is remarkable; substituents such as fluoro, methyl, methoxy, acetyl, formyl, benzoyl, nitro or nitrile are tolerated. Furthermore, this catalyst can be used at low loading, even for reactions of sterically hindered aryl bromides. Graphical Abstract.

Amide derivatives and intermediates for the synthesis thereof

Novel compounds which are amide derivatives represented by general formula (I) and medicinal preparations containing the same having an eosinophilic infiltration inhibitory effect based on a potent interferon (α,γ)-inducing activity and an exellent percutaneous absorbability and being efficacious in treating allergic inflammatory diseases such as atopic dermatitis, various tumors and viral diseases. In said formula, each symbol has the following meaning: R1 and R2 : each lower alkyl, etc.; X and Y: independently representing each oxygen, NR4, CR5 etc. (wherein R4 and R5 independently represent each hydrogen, an aromatic group, etc.); Z: an aromatic ring or heterocycle; R3 : hydrogen, lower alkoxy, etc.; g, i and k: independently representing each an integer of from 0 to 6; h, i and l: independently representing each an integer of 0 or 1; m: an integer of from 0 to 5; and n: an integer of from 2 to 12.

Process for the preparation of carboxylic acids and derivatives of them

The subject matter of the invention is a process for the preparation of carboxylic acids and derivatives of them of the general formula STR1 wherein R means hydrogen, or a C1-4 alkyl or a (C1-5 alkoxy)carbonyl group, R1 is as defined in claim 1, R7 stands for hydrogen or a C1-7 alkyl group and R8 means hydrogen or a carboxyl group, by reacting a 1,3-dioxane-4,6-dione derivative of the general formula STR2 wherein R9 stands for a C1-4 alkyl group or a phenyl group, optionally monosubstituted by halogen and R10 stands for hydrogen or a C1-5 alkyl group or R9 and R10 together form a pentamethylene group, and an aldehyde or ketone of the general formula STR3 in the presence of formic acid.

Process for the preparation of carboxylic acids and derivatives of them

The subject matter of the invention is a process for the preparation of carboxylic acids and derivatives of them of the general formula wherein Rmeans hydrogen, or a C1 4alkyl or a (C1 5alkoxy)carbonyl group, R1is as defined in claim 1, R7stands for hydrogen or a C1 7alkyl group and R8means hydrogen or a carboxyl group, by reacting a 1,3-dioxane-4,6-dione derivative of the general formula wherein R9stands for a C1 4alkyl group or a phenyl group, optionally monosubstituted by halogen and R10stands for hydrogen or a C1 5alkyl group or R9 and R10together form a pentamethylene group, and an aldehyde or ketone of the general formula in the presence of formic acid and of [a] amine(s) and, if desired, of an alcohol of the general formula, , R7 - OH VI,, , wherein R7is a C1 7alkyl group, at a temperature of 20 to 140°C, and/or, reducing an unsaturated 1,3-dioxane-4,6-dione derivative of the general formula and/or, a 1,3-dioxane-4,6-dione derivative of the general formula with formic acid in the presence of [a] amine(s) and, if desired, of an alcohol as above defined.

LONG-RANGE EXCITON COUPLING FROM DIPYRRINONE CHROMOPHORES

Dipyrrinone chromophores, attached by their acid termini to give (1R,2R)-cyclohexanediol dipropionate and diacetate esters (xanthobilirubinate and nor-xanthobilirubinate, respectively), interact through exciton coupling, as evidenced by intense bisignate