73725-47-0Relevant academic research and scientific papers
AMIDE COMPOUNDS
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Page 132-133, (2010/02/06)
A compound of the formula (I) wherein R1 is hydrogen, lower alkyl, lower alkenyl, halo(lower)alkyl, cyclo(lower)alkyl, lower alkoxy, lower alkylthio, acyl, optionally substituted aryl or NR3R4; R2 is hydrogen; or aryl or heteroaryl, each of which may be substituted; X is direct bond or bivalent residue derived from piperazine; Y is -(A1)n#191-(A2?)?m#191-, wherein n and m are independently 0 or 1); is bivalent residue derived from arene or heteroarene; and is bivalent residue derived from arene or heteroarene, or a salt thereof. The compound of the present invention and a salt thereof inhibit apolipoprotein B (Apo B) secretion and are useful as a medicament for prophylactic and treatment of diseases or conditions resulting from elevated circulating levels of Apo B.
A GENERAL ANIONIC MECHANISM FOR THERMODYNAMIC CONTROL OF REGIOSELECTIVITY IN N-ALKYLATION AND ACYLATION OF HETEROCYCLES
Bentley, T. William,Jones, Ray V.H.,Wareham, Peter J.
, p. 4013 - 4016 (2007/10/02)
Regioselective alkylation of 1,2,4-triazole (Ia,IIa) to 1-alkyl derivatives (Ib) may occur by nucleophilic displacement of the triazole anion, is thermodynamically-controlled (shown by a free energy diagram), and the position of equilibrium is relatively
