73734-75-5

Basic information

• Product Name: 1H-Benzimidazol-2-amine, 1-[(4-fluorophenyl)methyl]-N-[1-(3-phenyl-2-propenyl)-4-piperidinyl]-
• CAS NO: 73734-75-5
• Molecular Formula: C28H29FN4
• Molecular Weight: 440.563
• Mol File: 73734-75-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1H-Benzimidazol-2-amine, 1-[(4-fluorophenyl)methyl]-N-[1-(3-phenyl-2-propenyl)-4-piperidinyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazol-2-amine, 1-[(4-fluorophenyl)methyl]-N-[1-(3-phenyl-2-propenyl)-4-piperidinyl]-(73734-75-5)
• EPA Substance Registry System: 1H-Benzimidazol-2-amine, 1-[(4-fluorophenyl)methyl]-N-[1-(3-phenyl-2-propenyl)-4-piperidinyl]-(73734-75-5)

Safety Data

• Hazardous Substances Data: 73734-75-5(Hazardous Substances Data)

Upstream product

• 75970-64-8 1-[(4-fluorophenyl)methyl]-N-(4-piperidinyl)-1H-benzimidazol-2-amine dihydrobromide 
• 73734-07-3 (1H-benzimidazol-2-yl)-(1-ethoxycarbonyl-piperidin-4-yl)amine 
• 7191-70-0 N-(4''-fluorobenzyl)-1,2-phenylenediamine 
• 104-55-2 3-phenyl-propenal 
• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 84501-68-8 ethyl 4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinecarboxylate 
• 84946-20-3 2-chloro-1-(4-fluorobenzyl)-1H-benzimidazole 
• 459-46-1 4-Fluorobenzyl bromide 

Relevant articles and documents

Astemizole analogues with reduced hERG inhibition as potent antimalarial compounds

Astemizole is a H1-antagonist endowed with antimalarial activity, but has hERG liabilities. Systematic structural modifications of astemizole led to the discovery of analogues that display very potent activity as inhibitors of the growth of the Plasmodium parasite, but show a decreased hERG inhibition, when compared to astemizole. These compounds can be used as starting point for the development of a new class of antimalarials.