7374-90-5

Upstream product

• 583-53-9 2,3-dibromobenzene 
• 13153-47-4 (+/-)-exo-2-benzonorbornenol 
• 4453-90-1 1,4-dihydro-1,4-methanonaphthalene 
• 90364-56-0 (+/-)-exo-2-benzonorbornenyl acetate 
• 4453-90-1 1,4-dihydro-1,4-methanonaphthalene 
• 13153-47-4 (1S,4S)-1,2,3,4-Tetrahydro-1,4-methano-naphthalen-2-ol 
• 118-92-3 anthranilic acid 
• 542-92-7 cyclopenta-1,3-diene 
• 138751-00-5 tricyclo[6.2.1.0^2,7]undeca-2,4,6-trien-9-ol 

Downstream Products

• 58742-05-5 exo-2-(methylamino)benzobicyclo<2.2.1>heptene 
• 58742-05-5 endo-N-Methyl-2-aminobenzonorbornene 
• 93052-29-0 2-benzylamino-2-cyano-1,2,3,4-tetrahydro-1,4-methanonaphthalene 
• 115898-51-6 2-[(1S,2S,4S)-(1,2,3,4-Tetrahydro-1,4-methano-naphthalen-2-yl)oxy]-phenol 
• 115898-54-9 4-Bromo-2-[(1S,2S,4S)-(1,2,3,4-tetrahydro-1,4-methano-naphthalen-2-yl)oxy]-phenol 
• 115919-90-9 (1S,2S,4S)-2-(5-Bromo-2-methoxy-phenoxy)-1,2,3,4-tetrahydro-1,4-methano-naphthalene 
• 131408-21-4 4-Methoxy-3-[(1S,2S,4S)-(1,2,3,4-tetrahydro-1,4-methano-naphthalen-2-yl)oxy]-benzaldehyde 
• 115897-67-1 1-{4-Methoxy-3-[(1S,2S,4S)-(1,2,3,4-tetrahydro-1,4-methano-naphthalen-2-yl)oxy]-phenyl}-N¹-methyl-ethane-1,2-diamine 
• 115897-65-9 {4-Methoxy-3-[(1S,2S,4S)-(1,2,3,4-tetrahydro-1,4-methano-naphthalen-2-yl)oxy]-phenyl}-methylamino-acetonitrile 
• 115919-88-5 1-methyl-5-<3-(endo-benzobicyclo<2.2.1>hept-2-yloxy)-4-methoxyphenyl>-2-imidazolidinone 
• 58742-04-4 endo-2-amino-1,2,3,4-tetrahydro-1,4-methanonaphthalene 
• 2294-87-3 3-(2-propenyl)indene 

Relevant academic research and scientific papers

Highly flexible synthesis of indenylethylamines as ligand precursors for titanium complexes

Various indenylethylamines are synthesized for the first time by reductive amination of 2-(1H-inden-1-yl)acetaldehyde with commercially available primary amines. In addition, a new two-step synthesis of 2-(1 H-inden-1-yl)acetaldehyde that uses inexpensive indene and 2-bromo-1,1-diethoxyethane as starting materials is presented. Finally, a selected indenylethylamine is used as a ligand precursor for the synthesis of a corresponding indenylethylamido titanium complex. The latter result paves the way for applications of corresponding complexes as catalysts for important chemical reactions.

A convenient route to both enantiomers of endo-2-benzonorbornenol via lipase catalysed resolution of the racemic mixture

Resolution of racemic edo-benzonorbornenol (±)-4 was performed using Candida antarctica lipase (Novozym 435) in benzene (50°C/50 hours) with vinyl acetate as the acyl donor to afford (-)-endo-2-benzonorbornenol (-)-6 and their corresponding (+)-endo-2-ben

Ethanobicyclic amine derivatives for CNS disorders

Certain ethanobicyclic amine compounds are described for treatment of CNS disorders such as psychotic disorders, convulsions, dystonia and cerebral ischemia. Compounds of particular interest are of the formula STR1 wherein each of R1, R2, R3, R4, Y and Z is independently selected from hydrido, hydroxy, alkyl, cycloalkyl, cycloalkylalkyl, phenalkyl, phenyl, alkoxy, phenoxy, phenalkoxy, alkoxyalkyl, halo, haloalkyl and hydroxyalkyl; wherein R3 and R4 may be taken together to form oxo; wherein each of R5, R6, R7, R8, R9 and R10 is independently selected from hydrido, alkyl, cycloalkyl, hydroxyalkyl, fluoroalkyl, cycloalkylalkyl, alkoxyalkyl, phenalkyl and phenyl; wherein G within the nitrogen-containing cyclohetero moiety is selected from STR2 wherein R11 is selected from hydrido, alkyl, cycloalkyl, cycloalkylalkyl, phenyl, phenalkyl, alkoxyalkyl and hydroxyalkyl wherein each of R12 and R13 is independently selected from hydrido, hydroxy, alkyl, phenalkyl, phenyl, alkoxy, fluoroalkyl and fluoro; wherein m is one or two; wherein p is a number selected from zero through four, inclusive; wherein each of q and r is a number independently selected from one through three, inclusive, with the proviso that sum of q and r is a number from three through six, inclusive; with the further proviso that the nitrogen-containing cyclohetero moiety must be attached at one position selected from R3, R4, ring-position two, and ring-position three; or the pharmaceutically-acceptable salts thereof.

EVIDENCE FOR ANTI-BOND MIGRATION IN THE PHOTOREARRANGEMENT OF 2-D-EXOBENZONORBORNENYL-2-CHLORIDE

Photolysis of the title compund to exo-2-benzonorbornenyl methyl ether proceeds with scrambling of the deuterium between C1 and C2, indicative of migration of the anti aryl group.