73746-44-8

Basic information

• Product Name: 4,5-Diiodo-2-methyl-1H-imidazole
• Synonyms: 4,5-DIIODO-2-METHYL-1H-IMIDAZOLE;4,5-DIIODO-2-METHYLIMIDAZOLE
• CAS NO: 73746-44-8
• Molecular Formula: C4H4I2N2
• Molecular Weight: 333.9
• Product Categories: blocks;Imidazoles;Iodides;Imidazol&Benzimidazole;Imidaxoles
• Mol File: 73746-44-8.mol
• Article Data: 23

Chemical Properties

• Melting Point: 194-195°C
• Boiling Point: 434.9 °C at 760 mmHg
• Flash Point: 216.8 °C
• Appearance: crystal
• Density: 2.75 g/cm³
• Vapor Pressure: 2.33E-07mmHg at 25°C
• Refractive Index: 1.749
• PKA: 9.87±0.10(Predicted)
• CAS DataBase Reference: 4,5-Diiodo-2-methyl-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-Diiodo-2-methyl-1H-imidazole(73746-44-8)
• EPA Substance Registry System: 4,5-Diiodo-2-methyl-1H-imidazole(73746-44-8)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 36/37/38-36
• Safety Statements: 37/39-26
• Hazardous Substances Data: 73746-44-8(Hazardous Substances Data)

Usage

General Description

4,5-Diiodo-2-methyl-1H-imidazole is a chemical compound with the molecular formula C5H5I2N and a molecular weight of 310.901 g/mol. It is a derivative of imidazole, which is a five-membered heterocyclic compound containing nitrogen. This chemical is commonly used in organic synthesis and pharmaceutical research due to its versatile reactivity and potential medicinal properties. It has been studied for its antimicrobial and antifungal activities, and it has also been investigated as a potential candidate for the treatment of various medical conditions. Additionally, 4,5-Diiodo-2-methyl-1H-imidazole is also utilized as a reagent in chemical synthesis, particularly in the preparation of other imidazole derivatives.

InChI:InChI=1/C4H4I2N2/c1-2-7-3(5)4(6)8-2/h1H3,(H,7,8)

Upstream product

• 693-98-1 2-methylimidazole 

Downstream Products

• 73746-45-9 4⁽⁵⁾-iodo-2-methyl-1H-imidazole 
• 73746-45-9 4-iodo-2-methyl-1H-imidazole 
• 13369-82-9 4,5-diiodo-1,2-dimethylimidazole 

Relevant articles and documents

FLEXIBLE PIEZOELECTRIC AND FERROELECTRIC HALOIMIDAZOLE CRYSTALS

Provided herein are substituted haloimidazole crystals, the substituted haloimidazole crystal comprising a substituted haloimidazole compound wherein the substituents are selected from the group consisting of hydrogen, an alkyl, and a halogen. The substituted haloimidazole crystals may further comprise second substituted haloimidazole. The substituted haloimidazole crystals may be piezoelectric, ferroelectric, flexible, or any combination thereof. Also provided herein are methods for preparing substituted haloimidazole crystals.

Synthesis, crystal structure and antibacterial activity of new highly functionalized ionic compounds based on the imidazole nucleus

Several new highly functionalized imidazolium derivatives were synthesized, via appropriate synthetic routes, using imidazole, 1-methylimidazole and 2-phenyl-1-methylimidazole as key intermediates. The antibacterial activity of the prepared compounds was evaluated against: Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella thipymurium using disk-diffusion and MIC methods. Crystal X-ray structures are reported for six compounds.

Synthesis, structure-activity relationship studies, and identification of novel 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine derivatives as dual orexin receptor antagonists. Part 1

A novel series of non-peptidic OX1R/OX2R orexin receptor antagonists was prepared by heterocyclic replacement of the dimethoxyphenyl moiety contained in the tetrahydroisoquinoline core skeleton of almorexant. Introduction of substituted imidazole moieties delivered potent dual orexin receptor antagonists with nanomolar potency for hOX1R and hOX2R suitable for further fine-tuning. The preparation of these novel orexin receptor antagonists and the outcome of preliminary structure-activity relationship studies are described in this communication.